Sesn2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sesn2
sestrin 2
MGI:2651874

13 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sesn2^{Gt(RRJ141)Byg}/Sesn2^{Gt(RRJ141)Byg} involves: 129P2/OlaHsd	abnormal autophagy	J:189021
	abnormal gluconeogenesis	J:189021
	decreased adipocyte glucose uptake	J:189021
	decreased hepatocyte mitochondrial DNA content	J:189021
	decreased mitochondrial number	J:189021
	normal growth/size/body region phenotype	J:189021
	impaired glucose tolerance	J:189021
	increased liver triglyceride level	J:189021
	insulin resistance	J:189021
	macrovesicular hepatic steatosis	J:189021
Sesn2^{Gt(W077E06)Wrst}/Sesn2^{Gt(W077E06)Wrst} B6.129S2-Sesn2^{Gt(W077E06)Wrst}	decreased lung fibroblast proliferation	J:160854
	increased cellular sensitivity to hydrogen peroxide	J:160854
	increased fibroblast apoptosis	J:160854

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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