Klhl3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Klhl3
kelch-like 3
MGI:2445185

17 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Klhl3^tm1.1Esoh/Klhl3⁺ involves: C57BL/6	hyperkalemia	J:214330
	metabolic acidosis	J:214330
	salt-sensitive hypertension	J:214330
Klhl3^tm1.1Esoh/Klhl3^tm1.1Esoh involves: C57BL/6	hyperkalemia	J:214330
	metabolic acidosis	J:214330
	salt-sensitive hypertension	J:214330
Klhl3^tm1.1Slin/Klhl3⁺ Not Specified	abnormal physiological response to xenobiotic	J:284284
	acidemia	J:284284
	decreased circulating bicarbonate level	J:284284
	decreased renin activity	J:284284
	decreased urine potassium level	J:284284
	hyperkalemia	J:284284
	increased circulating aldosterone level	J:284284
	increased circulating chloride level	J:284284
	increased systemic arterial systolic blood pressure	J:284284
	metabolic acidosis	J:284284
Klhl3^tm1.1Slin/Klhl3^tm1.1Slin Not Specified	abnormal physiological response to xenobiotic	J:284284
	acidemia	J:284284
	decreased circulating bicarbonate level	J:284284
	decreased renin activity	J:284284
	decreased urine potassium level	J:284284
	hyperkalemia	J:284284
	increased circulating aldosterone level	J:284284
	increased circulating chloride level	J:284284
	increased systemic arterial systolic blood pressure	J:284284
	metabolic acidosis	J:284284
Klhl3^{tm1b(KOMP)Wtsi}/Klhl3^{tm1b(KOMP)Wtsi} C57BL/6N-Klhl3^{tm1b(KOMP)Wtsi}/H	decreased hemoglobin content	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating potassium level	J:211773
	increased heart weight	J:211773
Klhl3^tm2.1Esoh/Klhl3^tm2.1Esoh involves: C57BL/6 * C57BL/6J	abnormal distal convoluted tubule morphology	J:244278
	abnormal kidney morphology	J:244278
	acidemia	J:244278
	increased circulating chloride level	J:244278
	increased circulating potassium level	J:244278
	salt-sensitive hypertension	J:244278

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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