Tmc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tmc1
transmembrane channel-like gene family 1
MGI:2151016

27 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tmc1^baringo/Tmc1^baringo involves: C57BL/6	abnormal organ of Corti supporting cell morphology	J:181985
	abnormal outer hair cell stereociliary bundle morphology	J:181985
	normal behavior/neurological phenotype	J:181985
	cochlear degeneration	J:181985
	cochlear inner hair cell degeneration	J:181985
	cochlear outer hair cell degeneration	J:181985
	impaired hearing	J:181985
	organ of Corti degeneration	J:181985
Tmc1^dn/Tmc1⁺ involves: STOCK Grhl3^ct * M. m. molossinus	normal hearing/vestibular/ear phenotype	J:22445
Tmc1^dn/Tmc1⁺ STOCK Grhl3^ct/J	normal hearing/vestibular/ear phenotype	J:14069
Tmc1^dn/Tmc1^dn involves: STOCK Grhl3^ct * M. m. molossinus	abnormal ear morphology	J:22445
Tmc1^dn/Tmc1^dn involves: STOCK Grhl3^ct * M. m. molossinus	abnormal hearing physiology	J:22445
Tmc1^dn/Tmc1^dn STOCK Grhl3^ct/J	abnormal ear morphology	J:236, J:1600, J:6409, J:28899, J:32691
	abnormal hearing physiology	J:236, J:1600, J:6409, J:6806, J:28899, J:32693
	abnormal motor capabilities/coordination/movement	J:236
	abnormal otolith morphology	J:236
	abnormal scala media morphology	J:236
	abnormal stria vascularis morphology	J:236
	abnormal tectorial membrane morphology	J:236
	cochlear ganglion degeneration	J:236
	deafness	J:236
	Deiters cell degeneration	J:236
	head tossing	J:236
	normal nervous system phenotype	J:6806
	organ of Corti degeneration	J:236
	vestibular saccular macula degeneration	J:236
Tmc1^Mhdabth/Tmc1⁺ C3HeB/FeJ-Tmc1^Mhdabth/Ieg	abnormal gait	J:86685
Tmc1^Mhdabth/Tmc1⁺ C3HeB/FeJ-Tmc1^Mhdabth/Ieg	deafness	J:86685
Tmc1^nice/Tmc1^nice involves: C57BL/6	abnormal Deiters cell morphology	J:181985
	abnormal outer hair cell stereociliary bundle morphology	J:181985
	normal behavior/neurological phenotype	J:181985
	cochlear degeneration	J:181985
	cochlear inner hair cell degeneration	J:181985
	cochlear outer hair cell degeneration	J:181985
	impaired hearing	J:181985
Tmc1^stitch/Tmc1^stitch involves: BALB/c * C57BL/6	normal hearing/vestibular/ear phenotype	J:181985
Tmc1^stitch/Tmc1^stitch involves: BALB/c * C57BL/6	impaired hearing	J:181985
Tmc1^stitch/Tmc1^stitch involves: C57BL/6	abnormal outer hair cell stereociliary bundle morphology	J:181985
	normal behavior/neurological phenotype	J:181985
	cochlear degeneration	J:181985
	cochlear inner hair cell degeneration	J:181985
	cochlear outer hair cell degeneration	J:181985
	impaired hearing	J:181985
	organ of Corti degeneration	J:181985
Tmc1^tm1.1Ajg/Tmc1^tm1.1Ajg B6.129-Tmc1^tm1.1Ajg	abnormal hair cell mechanoelectric transduction	J:184419
	normal behavior/neurological phenotype	J:184419
	cochlear hair cell degeneration	J:184419
	cochlear inner hair cell degeneration	J:184419
	cochlear outer hair cell degeneration	J:184419
	deafness	J:184419
	increased or absent threshold for auditory brainstem response	J:184419

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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