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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Pelo
pelota mRNA surveillance and ribosome rescue factor
MGI:2145154
26 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Pelotm1.1Slac/Pelotm1.1Slac
involves: C57BL/6J * FVB/N
abnormal cerebellum morphology J:306384
embryonic lethality between implantation and somite formation, complete penetrance J:306384
Pelotm1Imad/Pelotm1Imad
either: 129 or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
abnormal extraembryonic endoderm formation J:228122
abnormal extraembryonic tissue morphology J:81781
abnormal germ layer development J:81781
absent extraembryonic coelom J:81781
absent inner cell mass proliferation J:81781
aneuploidy J:81781
decreased embryo size J:228122
embryonic growth arrest J:81781
embryonic growth retardation J:81781
embryonic lethality between implantation and somite formation, complete penetrance J:81781
polyploidy J:81781
Pelotm1Imad/Pelotm2Imad
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
no abnormal phenotype detected J:228122
Pelotm1Slac/Pelotm1Slac
En1tm2(cre)Wrst/En1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal brain interneuron morphology J:306384
abnormal cerebellum external granule cell layer morphology J:306384
cerebellum hypoplasia J:306384
decreased inferior colliculus size J:306384
decreased Purkinje cell number J:306384
decreased superior colliculus size J:306384
increased neuron apoptosis J:306384
increased neuronal precursor proliferation J:306384
loss of GABAergic neurons J:306384
Pelotm1Slac/Pelotm1Slac
Tg(Atoh1-cre)1Bfri/0
involves: C57BL/6J * CBA
abnormal cerebellum anterior lobe morphology J:306384
abnormal cerebellum external granule cell layer morphology J:306384
decreased cerebellar granule cell number J:306384
increased neuronal precursor proliferation J:306384
Pelotm1Slac/Pelotm1Slac
Tg(Gabra6-cre)B1Lfr/0
involves: C57BL/6J * DBA/2
normal nervous system phenotype J:306384
Pelotm2Imad/Pelotm2Imad
Tg(EIIa-cre)C5379Lmgd/?
involves: 129S1/Sv * 129X1/SvJ * FVB/N
embryonic lethality, complete penetrance J:228122

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory