Cyp4v3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
MGI:2142763

29 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyp4v3^em1(IMPC)Mbp/Cyp4v3^em1(IMPC)Mbp C57BL/6NCrl-Cyp4v3^em1(IMPC)Mbp/Mmucd	abnormal eye morphology	J:211773
	abnormal liver morphology	J:211773
	enlarged liver	J:211773
	hyperactivity	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Cyp4v3^em1Xsu/Cyp4v3^em1Xsu C57BL/6J-Cyp4v3^em1Xsu	abnormal electroretinogram waveform feature	J:321817
	abnormal eye physiology	J:321817
	abnormal glial cell physiology	J:321817
	abnormal lipid metabolism	J:321817
	abnormal photoreceptor inner segment morphology	J:321817
	abnormal photoreceptor outer segment morphology	J:321817
	abnormal retina cone cell outer segment morphology	J:321817
	abnormal retina inner nuclear layer morphology	J:321817
	abnormal retina inner plexiform layer morphology	J:321817
	abnormal retina morphology	J:321817
	abnormal retina pigment epithelium morphology	J:321817
	abnormal sclera morphology	J:321817
	decreased a-wave amplitude	J:321817
	decreased b-wave amplitude	J:321817
	decreased total retina thickness	J:321817
	increased microglial cell activation	J:321817
	increased susceptibility to age-related retinal degeneration	J:321817
	oxidative stress	J:321817
	retina deposits	J:321817
	retina photoreceptor degeneration	J:321817
	short retina rod cell outer segment	J:321817
	thin retina outer nuclear layer	J:321817
Cyp4v3^{tm1(KOMP)Vlcg}/Cyp4v3^{tm1(KOMP)Vlcg} B6(Cg)-Cyp4v3^{tm1(KOMP)Vlcg}	abnormal fatty acids level	J:230232
	abnormal optic choroid morphology	J:230232
	abnormal retina morphology	J:230232

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23