Insc Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Insc
INSC spindle orientation adaptor protein
MGI:1917942

20 phenotypes from 4 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn}/Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn} Tg(Nes-cre)1Wmz/0 involves: C57BL/6	abnormal brain development	J:178712
	abnormal cerebral cortex morphology	J:178712
	abnormal cortical intermediate zone morphology	J:178712
	abnormal cortical plate morphology	J:178712
	abnormal neuron morphology	J:178712
	abnormal neuronal precursor proliferation	J:178712
	abnormal radial glial cell morphology	J:178712
	abnormal stratification in cerebral cortex	J:178712
	increased neuron number	J:178712
	seizures	J:178712
	thickened cerebral cortex	J:178712
Gt(ROSA)26Sor^{tm1.1(CAG-Insc/GFP)Jakn}/Gt(ROSA)26Sor⁺ involves: C57BL/6	increased neuronal precursor cell number	J:178712
Insc^tm1.2Cayo/Insc^tm1.2Cayo B6.129(SJL)-Insc^tm1.2Cayo	abnormal cochlear hair cell morphology	J:214064
Insc^tm1.2Cayo/Insc^tm1.2Cayo B6.129(SJL)-Insc^tm1.2Cayo	abnormal cochlear hair cell stereociliary bundle morphology	J:214064
Insc^tm1Jakn/Insc^tm1Jakn Tg(Nes-cre)1Wmz/0 involves: C57BL/6	abnormal brain development	J:178712
	abnormal cerebral cortex morphology	J:178712
	abnormal cortical intermediate zone morphology	J:178712
	abnormal lateral ganglionic eminence morphology	J:178712
	abnormal neuron morphology	J:178712
	abnormal neuronal precursor proliferation	J:178712
	abnormal stratification in cerebral cortex	J:178712
	decreased brain size	J:178712
	decreased neuron number	J:178712
	enlarged lateral ventricles	J:178712
	thin cerebral cortex	J:178712
	thin cortical plate	J:178712

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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