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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Aire
autoimmune regulator
MGI:1338803
86 phenotypes from 9 alleles in 20 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Airetm1.1(cre)Ghr/Airetm1.1(cre)Ghr
Not Specified 		decreased dendritic cell number J:176844
decreased regulatory T cell number J:176844
increased dendritic cell number J:176844
Airetm1.1(NCOM)Mfgc/Aire+
C57BL/6N-Airetm1.1(NCOM)Mfgc/Tcp 		abnormal cholesterol homeostasis J:211773
Airetm1.1(NCOM)Mfgc/Airetm1.1(NCOM)Mfgc
C57BL/6N-Airetm1.1(NCOM)Mfgc/Tcp 		abnormal eye morphology J:211773
abnormal retina morphology J:211773
decreased prepulse inhibition J:211773
increased monocyte cell number J:211773
Airetm1.1Doi/Airetm1.1Doi
(B6.129S2-Airetm1.1Doi x NOD.129S2(B6)-Airetm1.1Doi)F1 		normal digestive/alimentary phenotype J:107432
Airetm1.1Doi/Airetm1.1Doi
B6.129S2-Airetm1.1Doi/Doi 		increased autoantibody level J:107432
increased incidence of corneal inflammation J:107432
lung inflammation J:107432
retina degeneration J:107432
salivary gland inflammation J:107432
stomach inflammation J:107432
Airetm1.1Doi/Airetm1.1Doi
C.129S2-Airetm1.1Doi/Doi 		increased autoantibody level J:107432
increased incidence of corneal inflammation J:107432
liver inflammation J:107432
lung inflammation J:107432
ovary inflammation J:107432
prostate gland inflammation J:107432
retina degeneration J:107432
salivary gland inflammation J:107432
stomach inflammation J:107432
Airetm1.1Doi/Airetm1.1Doi
involves: 129S2/SvPas * C57BL/6 		abnormal thymus medulla morphology J:83422
increased autoantibody level J:119475
increased susceptibility to autoimmune disorder J:83422
increased T cell number J:83422
stomach inflammation J:119475
Airetm1.1Doi/Airetm1.1Doi
involves: 129S2/SvPas * C57BL/6 * NOD 		liver inflammation J:107432
lung inflammation J:107432
pancreas inflammation J:107432
salivary gland inflammation J:107432
stomach inflammation J:107432
Airetm1.1Doi/Airetm1.1Doi
NOD.129S2(B6)-Airetm1.1Doi/Doi 		cachexia J:107432
increased autoantibody level J:107432
increased incidence of corneal inflammation J:107432
liver inflammation J:107432
lung inflammation J:107432
ovary inflammation J:107432
pancreas inflammation J:107432
premature death J:107432
prostate gland inflammation J:107432
retina degeneration J:107432
salivary gland inflammation J:107432
stomach inflammation J:107432
thyroid gland inflammation J:107432
Airetm1.1Doi/Airetm1.1Doi
NOD.129S2-Airetm1.1Doi 		abnormal CD4-positive, alpha-beta T cell physiology J:135154
chronic pancreas inflammation J:135154
insulitis J:135154
lacrimal gland inflammation J:135154
lung inflammation J:135154
salivary gland inflammation J:135154
stomach inflammation J:135154
thyroid gland inflammation J:135154
uveitis J:135154
Airetm1.1Doi/Airetm1.1Doi
SJL.129S2-Airetm1.1Doi/Doi 		increased autoantibody level J:107432
liver inflammation J:107432
lung inflammation J:107432
ovary inflammation J:107432
pancreas inflammation J:107432
prostate gland inflammation J:107432
salivary gland inflammation J:107432
stomach inflammation J:107432
Airetm1Mand/Aire+
involves: 129P2/OlaHsd * C57BL/6 		lacrimal gland inflammation J:135154
salivary gland inflammation J:135154
Airetm1Mand/Aire+
NOD.129P2-Airetm1Mand 		abnormal CD4-positive, alpha-beta T cell physiology J:135154, J:188686
abnormal chemokine level J:188686
abnormal nervous system morphology J:188686
abnormal sciatic nerve morphology J:135154, J:188686
chronic pancreas inflammation J:135154
CNS inflammation J:135154
demyelination J:188686
hindlimb paralysis J:135154
increased autoantibody level J:188686
increased CXCL10 level J:188686
increased inflammatory response J:188686
increased susceptibility to autoimmune diabetes J:135154, J:188686
insulitis J:135154
lacrimal gland inflammation J:135154
limb grasping J:188686
paralysis J:188686
salivary gland inflammation J:135154
thyroid gland inflammation J:135154
Airetm1Mand/Airetm1.1Doi
NOD.129-Airetm1Mand/Airetm1.1Doi 		abnormal CD4-positive, alpha-beta T cell physiology J:135154
chronic pancreas inflammation J:135154
insulitis J:135154
lacrimal gland inflammation J:135154
lung inflammation J:135154
salivary gland inflammation J:135154
stomach inflammation J:135154
thyroid gland inflammation J:135154
uveitis J:135154
weight loss J:135154
Airetm1Mand/Airetm1Mand
involves: 129P2/OlaHsd * C57BL/6 		eye inflammation J:135154
lacrimal gland inflammation J:135154
salivary gland inflammation J:135154
Airetm1Mmat/Airetm1Mmat
B6.Cg-Airetm1Mmat 		autoimmune response J:96580
salivary gland inflammation J:96580
Airetm1Mmat/Airetm1Mmat
C.Cg-Airetm1Mmat 		abnormal stomach mucosa morphology J:96580
increased autoantibody level J:96580
stomach inflammation J:96580
Airetm1Mmat/Airetm1Mmat
involves: C57BL/6 * CBA 		autoimmune response J:96580
decreased tear production J:96580
normal endocrine/exocrine gland phenotype J:96580
lacrimal gland inflammation J:96580
pancreas inflammation J:96580
parotid gland inflammation J:96580
reduced fertility J:96580
stomach inflammation J:96580
submandibular gland inflammation J:96580
Airetm1Mmat/Airetm2Mmat
involves: C57BL/6 * CBA 		abnormal thymus morphology J:141379
autoimmune response J:141379
Airetm1Pltn/Aire+
involves: 129S4/SvJae * C57BL/6 		reduced fertility J:77873
Airetm1Pltn/Airetm1Pltn
B6.129S4-Airetm1Pltn 		abnormal definitive hematopoiesis J:115076
abnormal metallophilic macrophage morphology J:115076
abnormal myelopoiesis J:115076
abnormal spleen marginal zone morphology J:115076
decreased body weight J:115076
decreased follicular B cell number J:115076
enlarged spleen J:115076
normal immune system phenotype J:115076
increased B cell derived lymphoma incidence J:115076
increased B cell number J:115076
increased marginal zone B cell number J:115076
increased monocyte cell number J:115076
increased spleen weight J:115076
liver inflammation J:115076
Airetm1Pltn/Airetm1Pltn
involves: 129S4/SvJae * C57BL/6 		abnormal T cell morphology J:77873
absent adrenal gland J:77873
increased autoantibody level J:77873
increased T cell proliferation J:77873
infertility J:77873
liver inflammation J:77873
thymus atrophy J:77873
Airetm1Ptsn/Airetm1Ptsn
C57BL/6-Airetm1Ptsn 		abnormal T cell activation J:145910
abnormal thymus medulla morphology J:145910
increased autoantibody level J:145910
parotid gland inflammation J:145910
reduced male fertility J:145910
sublingual gland inflammation J:145910
uveitis J:145910
vitreous body inflammation J:145910
Airetm1Ptsn/Airetm1Ptsn
C.B6-Airetm1Ptsn 		abnormal adaptive immunity J:174653
abnormal cytokine level J:174653
abnormal regulatory T cell physiology J:174653
abnormal T-helper 1 physiology J:174653
abnormal T-helper 17 cell physiology J:174653
decreased susceptibility to fungal infection J:174653
increased interleukin-6 secretion J:174653
increased interleukin-12 secretion J:174653
increased interleukin-23 secretion J:174653
increased susceptibility to autoimmune disorder J:174653
increased susceptibility to fungal infection J:174653
increased tumor necrosis factor secretion J:174653
stomach inflammation J:174653
Airetm2Mmat/Airetm2Mmat
involves: C57BL/6 * CBA 		abnormal thymus morphology J:141379
abnormal thymus physiology J:141379
absent Hassall's corpuscle J:141379
autoimmune response J:141379
Airetm3(cre)Mmat/?
Not Specified 		no abnormal phenotype detected J:160217
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory