Lss Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lss
lanosterol synthase
MGI:1336155

34 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lss^em1Zhaol/Lss^em1Zhaol C57BL/6J-Lss^em1Zhaol	abnormal lens development	J:316796
	abnormal lens fiber morphology	J:316796
	developmental cataract	J:316796
	disorganized secondary lens fibers	J:316796
	neonatal lethality, complete penetrance	J:316796
	small lens	J:316796
Lss^{tm1b(KOMP)Wtsi}/Lss⁺ C57BL/6N-Lss^{tm1b(KOMP)Wtsi}/Ieg	abnormal lens morphology	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased leukocyte cell number	J:211773
Lss^{tm1b(KOMP)Wtsi}/Lss^{tm1b(KOMP)Wtsi} C57BL/6N-Lss^{tm1b(KOMP)Wtsi}/Bay	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Lss^{tm1b(KOMP)Wtsi}/Lss^{tm1b(KOMP)Wtsi} C57BL/6N-Lss^{tm1b(KOMP)Wtsi}/Ieg	preweaning lethality, complete penetrance	J:211773
Lss^{tm1c(KOMP)Wtsi}/Lss^{tm1c(KOMP)Wtsi} Tg(KRT14-cre)1Amc/0 involves: C57BL/6 * C57BL/6NTac * CBA	abnormal cholesterol homeostasis	J:286778
	abnormal epidermal layer morphology	J:286778
	abnormal skin morphology	J:286778
	absent vibrissae	J:286778
	dehydration	J:286778
	impaired skin barrier function	J:286778
	neonatal lethality, complete penetrance	J:286778
	weight loss	J:286778
Lss^{tm1c(KOMP)Wtsi}/Lss^{tm1c(KOMP)Wtsi} Tg(KRT14-cre/ERT)20Efu/0 involves: C57BL/6 * C57BL/6NTac * CD-1 * ICR	abnormal epidermal layer morphology	J:286778
	abnormal hair follicle morphology	J:286778
	abnormal outer ear skin morphology	J:286778
	abnormal sebaceous gland physiology	J:286778
	abnormal tail morphology	J:286778
	acanthosis	J:286778
	alopecia	J:286778
	epidermal hyperplasia	J:286778
	hyperkeratosis	J:286778
	parakeratosis	J:286778
	sebaceous gland hyperplasia	J:286778
Lss^{tm1c(KOMP)Wtsi}/Lss^{tm1c(KOMP)Wtsi} Tg(Pax6-GFP/cre)1Rilm/0 involves: C57BL/6 * C57BL/6NTac * FVB/N	abnormal lens morphology	J:286778
	cataract	J:286778
	decreased retina ganglion cell number	J:286778
	microphthalmia	J:286778
	thin retina ganglion layer	J:286778
	thin retina inner nuclear layer	J:286778

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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