Pla2g4a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
MGI:1195256

41 phenotypes from 2 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pla2g4a^tm1Jvb/Pla2g4a^tm1Jvb involves: 129S4/SvJae	abnormal heart left ventricle morphology	J:99600
	abnormal heart right ventricle morphology	J:76813
	abnormal mast cell differentiation	J:54619
	abnormal pulmonary vascular resistance	J:76813
	abnormal response to injury	J:76813
	cardiac hypertrophy	J:99600
	normal cardiovascular system phenotype	J:99600
	decreased cerebral infarct size	J:39681
	decreased litter size	J:39681
	decreased physiological sensitivity to xenobiotic	J:120035, J:278285
	decreased susceptibility to dopaminergic neuron neurotoxicity	J:120035
	decreased susceptibility to ischemic brain injury	J:39681
	enlarged heart	J:99600
	increased dopamine level	J:120035
	increased heart left ventricle weight	J:99600
	increased heart weight	J:99600
	increased mast cell degranulation	J:54619
	increased myocardial fiber size	J:99600
	increased response of heart to induced stress	J:99600
	increased skeletal muscle fiber diameter	J:99600
	maternal effect	J:39681
	polycythemia	J:76813
	reduced female fertility	J:39681
Pla2g4a^tm1Jvb/Pla2g4a^tm1Jvb involves: 129S4/SvJae * BALB/c	normal immune system phenotype	J:110309
Pla2g4a^tm1Jvb/Pla2g4a^tm1Jvb involves: 129S4/SvJae * C57BL/6	abnormal response/metabolism to endogenous compounds	J:114240
	decreased body weight	J:114240
	decreased urine osmolality	J:114240
	increased blood osmolality	J:114240
Pla2g4a^tm1Jvb/Pla2g4a^tm1Jvb involves: 129S4/SvJae * C57BL/6J	decreased incidence of tumors by chemical induction	J:91526
Pla2g4a^tm1Tksh/Pla2g4a^tm1Tksh B6.129P2-Pla2g4a^tm1Tksh	abnormal cytokine level	J:107430
	decreased interferon-gamma secretion	J:107430
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:107430
	decreased tumor necrosis factor secretion	J:107430
	normal immune system phenotype	J:197334
Pla2g4a^tm1Tksh/Pla2g4a^tm1Tksh involves: 129P2/OlaHsd * C57BL/6J	abnormal renal tubule morphology	J:39254
	decreased airway resistance	J:39254
	decreased litter size	J:39254
	normal growth/size/body region phenotype	J:39254
	increased susceptibility to type I hypersensitivity reaction	J:39254
	parturition failure	J:39254
Pla2g4a^tm1Tksh/Pla2g4a^tm1Tksh NOD.129P2(B6)-Pla2g4a^tm1Tksh	abnormal macrophage physiology	J:99775
	impaired glucose tolerance	J:99775
	insulitis	J:99775

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