Polr1a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Polr1a
polymerase (RNA) I polypeptide A
MGI:1096397

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	telencephalon hypoplasia	J:335489
Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	telencephalon hypoplasia	J:335489
Foxg1^{tm1.1(cre)Ddmo}/Foxg1⁺ Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	telencephalon hypoplasia	J:335489
Foxg1^{tm1.1(cre)Ddmo}/0 Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} involves: 129S1/Sv * 129T/Sv * 129X1/SvJ * C57BL/6N	telencephalon hypoplasia	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	abnormal heart right ventricle outflow tract morphology	J:335489
	absent heart right ventricle	J:335489
	enlarged heart	J:335489
	heart right ventricle hypoplasia	J:335489
	ventricular septal defect	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA	normal cardiovascular system phenotype	J:335489
	cleft chin	J:335489
	cleft palate	J:335489
	facial cleft	J:335489
	frontal bone hypoplasia	J:335489
	nasal bone hypoplasia	J:335489
	short mandible	J:335489
	temporal bone squamous part hypoplasia	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1a(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1)10Rth/0 involves: 129S1/Sv 129X1/SvJ * C57BL/6N	decreased heart left ventricle wall thickness	J:335489
	embryonic lethality during organogenesis, complete penetrance	J:335489
	flat forehead	J:335489
	increased vascular permeability	J:335489
	lethality throughout fetal growth and development	J:335489
	persistent truncus arteriosus	J:335489
	pharyngeal arch artery hypoplasia	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	abnormal heart right ventricle outflow tract morphology	J:335489
	absent heart right ventricle	J:335489
	enlarged heart	J:335489
	heart right ventricle hypoplasia	J:335489
	ventricular septal defect	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0 Not Specified	cardiovascular system phenotype	J:335489
	cleft chin	J:335489
	cleft palate	J:335489
	facial cleft	J:335489
	frontal bone hypoplasia	J:335489
	nasal bone hypoplasia	J:335489
	short mandible	J:335489
	temporal bone squamous part hypoplasia	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1c(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1)10Rth/0 involves: 129S1/Sv 129X1/SvJ * C57BL/6N	decreased heart left ventricle wall thickness	J:335489
	embryonic lethality during organogenesis, complete penetrance	J:335489
	flat forehead	J:335489
	increased vascular permeability	J:335489
	lethality throughout fetal growth and development	J:335489
	persistent truncus arteriosus	J:335489
	pharyngeal arch artery hypoplasia	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA	cleft palate	J:335489
	facial cleft	J:335489
	midline cleft upper lip	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1)10Rth/0 involves: 129S1/Sv 129X1/SvJ * C57BL/6 * C57BL/6N	normal cardiovascular system phenotype	J:335489
	facial cleft	J:335489
	flat forehead	J:335489
	lethality throughout fetal growth and development	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Mef2c-cre)2Blk/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	abnormal heart right ventricle outflow tract morphology	J:335489
	absent heart right ventricle	J:335489
	enlarged heart	J:335489
	heart right ventricle hypoplasia	J:335489
	ventricular septal defect	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Sox10-cre)1Wdr/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * CBA	cardiovascular system phenotype	J:335489
	cleft chin	J:335489
	cleft palate	J:335489
	facial cleft	J:335489
	frontal bone hypoplasia	J:335489
	nasal bone hypoplasia	J:335489
	short mandible	J:335489
	temporal bone squamous part hypoplasia	J:335489
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^{tm1d(EUCOMM)Hmgu}/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1)10Rth/0 involves: 129S1/Sv 129X1/SvJ * C57BL/6N	decreased heart left ventricle wall thickness	J:335489
	embryonic lethality during organogenesis, complete penetrance	J:335489
	flat forehead	J:335489
	increased vascular permeability	J:335489
	lethality throughout fetal growth and development	J:335489
	persistent truncus arteriosus	J:335489
	pharyngeal arch artery hypoplasia	J:335489

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23