Gjb6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gjb6
gap junction protein, beta 6
MGI:107588

32 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gjb6^tm1.1Fama/Gjb6⁺ involves: 129P2/OlaHsd * C57BL/6 * SJL	normal hearing/vestibular/ear phenotype	J:166362
Gjb6^tm1.1Fama/Gjb6^tm1.1Fama involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal cochlear potential	J:166362
	increased or absent threshold for auditory brainstem response	J:166362
Gjb6^tm1.1Mcsa/Gjb6^tm1.1Mcsa involves: 129 * BALB/c * C57BL/6	normal hearing/vestibular/ear phenotype	J:193913
Gjb6^tm1Kwi/Gjb6⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal nervous system physiology	J:89971
Gjb6^tm1Kwi/Gjb6⁺ involves: 129P2/OlaHsd * C57BL/6J	decreased dopamine level	J:89971
Gjb6^tm1Kwi/Gjb6^tm1Kwi involves: 129P2/OlaHsd	deafness	J:166362
	decreased endocochlear potential	J:166362
	increased or absent threshold for auditory brainstem response	J:166362
Gjb6^tm1Kwi/Gjb6^tm1Kwi involves: 129P2/OlaHsd * C57BL/6	abnormal amino acid level	J:120823
	abnormal blood-inner ear barrier function	J:120823
	abnormal cochlear endolymph ionic homeostasis	J:80917
	abnormal hair cell physiology	J:178055
	abnormal stria vascularis morphology	J:120823
	abnormal stria vascularis vasculature morphology	J:120823
	absent endocochlear potential	J:80917
	absent pinna reflex	J:80917
	cochlear hair cell degeneration	J:80917
	cochlear inner hair cell degeneration	J:80917, J:119517
	cochlear outer hair cell degeneration	J:80917, J:119517
	deafness	J:119517
	decreased endocochlear potential	J:80917, J:119517
	normal immune system phenotype	J:85065
	increased or absent threshold for auditory brainstem response	J:80917, J:119517
	organ of Corti degeneration	J:119517
	sensorineural hearing loss	J:80917
Gjb6^tm1Kwi/Gjb6^tm1Kwi involves: 129P2/OlaHsd * C57BL/6J	abnormal nervous system physiology	J:89971
	decreased vertical activity	J:89971
	increased anxiety-related response	J:89971
	normal nervous system phenotype	J:89971
Gjb6^tm2.2Kwi/Gjb6^tm2.2Kwi involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CD-1 * SJL	abnormal epidermal layer morphology	J:208123
	abnormal sebaceous gland morphology	J:208123
	decreased threshold for auditory brainstem response	J:208123
	enlarged sebaceous gland	J:208123
	greasy coat	J:208123
	hyperkeratosis	J:208123
	impaired hearing	J:208123
	increased or absent threshold for auditory brainstem response	J:208123
	increased sebocyte number	J:208123

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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