Scn8a Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Scn8a
sodium channel, voltage-gated, type VIII, alpha
MGI:103169

27 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gars1^C201R/Gars1⁺ Scn8a^m10J/Scn8a⁺ involves: BALB/cAnN * C3H/HeJ * FVB/NJ	abnormal motor neuron innervation pattern	J:240096
	abnormal neuromuscular synapse morphology	J:240096
	decreased nerve conduction velocity	J:240096
Gars1^Nmf249/Gars1⁺ Scn8a^m10J/Scn8a⁺ involves: C57BL/6J * FVB/NJ	abnormal neuromuscular synapse morphology	J:240096
	decreased nerve conduction velocity	J:240096
	skeletal muscle atrophy	J:240096
Scn1a^tm1.1Aesc/Scn1a⁺ Scn8a^med-jo/Scn8a⁺ involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * DBA/2WyDi	normal behavior/neurological phenotype	J:170734
Scn1a^tm1.1Aesc/Scn1a^tm1.1Aesc Scn8a^med-jo/Scn8a⁺ involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * DBA/2WyDi	decreased survivor rate	J:170734
	postnatal lethality, incomplete penetrance	J:170734
Scn1a^tm1Wac/Scn1a⁺ Scn8a^med-jo/Scn8a⁺ involves: 129 * C57BL/6J * DBA/2WyDi * FVB/NJ	abnormal spike wave discharge	J:129998
	normal mortality/aging	J:129998
	normal nervous system phenotype	J:129998
Scn1a^tm1Wac/Scn1a^tm1Wac Scn8a^med-jo/Scn8a⁺ involves: 129 * C57BL/6J * DBA/2WyDi * FVB/NJ	postnatal lethality, complete penetrance	J:129998
Scn8a^med-J/Scn8a^med-J Scnm1^m1R/Scnm1^m1R involves: C57BL/6 * STOCK Krt71^Ca	normal behavior/neurological phenotype	J:141236
	postnatal lethality	J:141236
Scn8a^med-J/Scn8a^med-J Scnm1^s/Scnm1⁺ involves: C3HeB/FeJ * C57BL/6J	abnormal action potential	J:108906
	abnormal CNS synaptic transmission	J:108906
	abnormal posture	J:108906
	impaired hearing	J:108906
	increased susceptibility to age-related hearing loss	J:108906
	paraparesis	J:108906
	tremors	J:108906
Scn8a^med-J/Scn8a^med-J Scnm1^s/Scnm1^s involves: C57BL/6J	ataxia	J:79617
	dystonia	J:79617
	muscular atrophy	J:79617
	paralysis	J:79617
	premature death	J:79617
Scn8a^med-J/Scn8a^med-J Scnm1^s/Scnm1^s involves: C57BL/6J * STOCK Krt71^Ca	abnormal cell physiology	J:141236
	muscle weakness	J:141236
	premature death	J:141236
Scn8a^med-J/Scn8a^med-J Scnm1^tm1.1Mm/Scnm1^tm1.1Mm involves: C57BL/6 * FVB * SJL * STOCK Krt71^Ca	abnormal cell physiology	J:141236
	hindlimb paralysis	J:141236
	premature death	J:141236

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