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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dync1h1
dynein cytoplasmic 1 heavy chain 1
MGI:103147
28 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Dync1h1Cra1/Dync1h1+
C3HeB/FeJ-Dync1h1Cra1 		decreased grip strength J:83128
decreased motor neuron number J:83128
impaired coordination J:83128, J:107901
motor neuron degeneration J:83128
muscle spasm J:83128
Dync1h1Cra1/Dync1h1+
involves: C3HeB/FeJ * C57BL/6 		muscle spasm J:83128
Dync1h1Cra1/Dync1h1Cra1
C3HeB/FeJ-Dync1h1Cra1 		aphagia J:83128
decreased spinal cord ventral horn cell number J:83128
neonatal lethality, complete penetrance J:83128
neuronal intranuclear inclusions J:83128
paralysis J:83128
Dync1h1Loa/Dync1h1+
C3H/HeH-Dync1h1Loa 		abnormal grip strength J:83128
abnormal motor neuron innervation pattern J:83128
decreased motor neuron number J:83128
impaired coordination J:83128
motor neuron degeneration J:83128
muscle spasm J:83128
Dync1h1Loa/Dync1h1+
involves: C3H/HeH * C57BL/6 		muscle spasm J:83128
Dync1h1Loa/Dync1h1Loa
C3H/HeH-Dync1h1Loa 		abnormal axonal transport J:83128
abnormal motor neuron innervation pattern J:83128
absent suckling reflex J:83128
aphagia J:83128
decreased spinal cord ventral horn cell number J:83128
neonatal lethality, complete penetrance J:83128
neuronal intranuclear inclusions J:83128
paralysis J:83128
Dync1h1Swl/Dync1h1+
involves: 101/H * C3H/HeH 		abnormal postnatal growth J:13469
abnormal resting posture J:13469
impaired limb coordination J:11963, J:13469
jerky movement J:13469
male infertility J:11963
Dync1h1TgTn(sb-rtTA,Tyr)2489AOve/Dync1h1TgTn(sb-rtTA,Tyr)2489AOve
FVB/N-Dync1h1TgTn(sb-rtTA,Tyr)2489AOve 		embryonic lethality between somite formation and embryo turning, complete penetrance J:175597
Dync1h1tm1.1Sjki/Dync1h1+
involves: 129 * 129S1/SvImJ * C57BL/6 * C57BL/6J 		abnormal neuromuscular synapse morphology J:264493
decreased grip strength J:264493
impaired coordination J:264493
increased susceptibility to weight gain J:264493
limb grasping J:264493
normal muscle phenotype J:264493
Dync1h1tm1dIcs/Dync1h1+
C57BL/6N-Dync1h1tm1dIcs/Ics 		abnormal vocalization J:211773
decreased locomotor activity J:211773
impaired glucose tolerance J:211773
Dync1h1tm1Noh/Dync1h1tm1Noh
involves: 129S4/SvJae 		embryonic lethality between implantation and somite formation, complete penetrance J:78610
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory