Scnn1a Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Scnn1a
sodium channel, nonvoltage-gated 1 alpha
MGI:101782

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Scnn1a^tm1.2Hum/Scnn1a^tm1.2Hum Spint2^{Gt(KST272)Byg}/Spint2^{Gt(KST272)Byg} involves: 129/Sv * 129P2/OlaHsd	embryonic lethality, complete penetrance	J:188121
Scnn1a^tm1Rss/Scnn1a^tm1Rss Tg(CMV-Scnn1a)1352Rss/0 involves: 129P2/OlaHsd * NMRI	abnormal renal sodium reabsorption	J:43583
	decreased intestinal epithelial sodium ion transmembrane transport	J:43583
	decreased urine bicarbonate level	J:43583
	decreased urine pH	J:43583
	increased circulating aldosterone level	J:43583
	increased urine sodium level	J:43583
	metabolic acidosis	J:43583
	postnatal growth retardation	J:43583
	postnatal lethality, incomplete penetrance	J:43583
	normal respiratory system phenotype	J:43583

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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