GO Annotations Graph

• Symbol: Ryr3
• Name: ryanodine receptor 3
• ID: MGI:99684

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0005262	calcium channel activity	IEA	J:72247
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0048763	calcium-induced calcium release activity	ISO	J:155856
Molecular Function	GO:0048763	calcium-induced calcium release activity	IBA	J:265628
Molecular Function	GO:0015278	calcium-release channel activity	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	ISO	J:155856
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	IBA	J:265628
Cellular Component	GO:0034704	calcium channel complex	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IEA	J:60000
Cellular Component	GO:0030314	junctional membrane complex	IDA	J:56913
Cellular Component	GO:0030314	junctional membrane complex	IDA	J:56913
Cellular Component	GO:0030314	junctional membrane complex	IDA	J:56913
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0016529	sarcoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:87932
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:72247
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:45244
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:45244
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:45244
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA	J:265628
Biological Process	GO:0006941	striated muscle contraction	IBA	J:265628
Biological Process	GO:0006941	striated muscle contraction	IMP	J:45244
Biological Process	GO:0006941	striated muscle contraction	IMP	J:45244
Biological Process	GO:0006941	striated muscle contraction	IMP	J:45244
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247