GO Annotations Graph

• Symbol: Vil1
• Name: villin 1
• ID: MGI:98930

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:72247
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	J:135256
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0035727	lysophosphatidic acid binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:172887
Molecular Function	GO:0005515	protein binding	IPI	J:206363
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0032432	actin filament bundle	ISO	J:164563
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0005903	brush border	IDA	J:300338
Cellular Component	GO:0005903	brush border	TAS	J:57346
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0030175	filopodium	IDA	J:169904
Cellular Component	GO:0030175	filopodium	ISO	J:164563
Cellular Component	GO:0032433	filopodium tip	IDA	J:169904
Cellular Component	GO:0030027	lamellipodium	IDA	J:172887
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IBA	J:265628
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0005902	microvillus	IDA	J:173338
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Biological Process	GO:0051693	actin filament capping	ISO	J:164563
Biological Process	GO:0030042	actin filament depolymerization	ISO	J:164563
Biological Process	GO:0030041	actin filament polymerization	ISO	J:164563
Biological Process	GO:0051014	actin filament severing	ISO	J:164563
Biological Process	GO:0051014	actin filament severing	IBA	J:265628
Biological Process	GO:0045010	actin nucleation	IEA	J:72247
Biological Process	GO:0008154	actin polymerization or depolymerization	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0051016	barbed-end actin filament capping	ISO	J:164563
Biological Process	GO:0051016	barbed-end actin filament capping	IBA	J:265628
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:164563
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	IDA	J:172887
Biological Process	GO:0060327	cytoplasmic actin-based contraction involved in cell motility	ISO	J:164563
Biological Process	GO:0007010	cytoskeleton organization	IEA	J:72247
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001951	intestinal D-glucose absorption	IGI	J:219622
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	ISO	J:164563
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ISO	J:164563
Biological Process	GO:2000394	positive regulation of lamellipodium morphogenesis	ISO	J:164563
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IGI	J:219622
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	IGI	J:219622
Biological Process	GO:0051125	regulation of actin nucleation	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:2000392	regulation of lamellipodium morphogenesis	IDA	J:172887
Biological Process	GO:2000392	regulation of lamellipodium morphogenesis	IBA	J:265628
Biological Process	GO:0032532	regulation of microvillus length	IGI	J:219622
Biological Process	GO:0061041	regulation of wound healing	IDA	J:172887
Biological Process	GO:0009617	response to bacterium	ISO	J:164563
Biological Process	GO:1902896	terminal web assembly	IGI	J:219622