GO Annotations Graph

• Symbol: Smpd1
• Name: sphingomyelin phosphodiesterase 1, acid lysosomal
• ID: MGI:98325

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	IDA	J:35194
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	IDA	J:326897
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	IDA	J:326897
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	IDA	J:100158
Molecular Function	GO:0061750	acid sphingomyelin phosphodiesterase activity	IDA	J:190369
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0034480	phosphatidylcholine phospholipase C activity	IEA	J:72245
Molecular Function	GO:0004767	sphingomyelin phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IDA	J:35194
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0036019	endolysosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IDA	J:35194
Cellular Component	GO:0005615	extracellular space	IDA	J:326897
Cellular Component	GO:0005615	extracellular space	IDA	J:326897
Cellular Component	GO:0042599	lamellar body	ISO	J:155856
Cellular Component	GO:0005811	lipid droplet	IEA	J:60000
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0046513	ceramide biosynthetic process	ISO	J:164563
Biological Process	GO:0046513	ceramide biosynthetic process	ISO	J:155856
Biological Process	GO:0046513	ceramide biosynthetic process	IMP	J:35076
Biological Process	GO:0046513	ceramide biosynthetic process	IBA	J:265628
Biological Process	GO:0046513	ceramide biosynthetic process	IDA	J:326897
Biological Process	GO:0046513	ceramide biosynthetic process	IDA	J:326897
Biological Process	GO:0006672	ceramide metabolic process	IMP	J:190369
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:184361
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0043407	negative regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0001778	plasma membrane repair	ISO	J:164563
Biological Process	GO:0001778	plasma membrane repair	IDA	J:326897
Biological Process	GO:0001778	plasma membrane repair	IDA	J:326897
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:35076
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045807	positive regulation of endocytosis	ISO	J:164563
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	ISO	J:164563
Biological Process	GO:0046598	positive regulation of viral entry into host cell	ISO	J:164563
Biological Process	GO:0042220	response to cocaine	ISO	J:155856
Biological Process	GO:0070555	response to interleukin-1	ISO	J:164563
Biological Process	GO:0010212	response to ionizing radiation	ISO	J:164563
Biological Process	GO:0010212	response to ionizing radiation	IMP	J:35076
Biological Process	GO:0034612	response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0034340	response to type I interferon	ISO	J:164563
Biological Process	GO:0009615	response to virus	ISO	J:164563
Biological Process	GO:0006685	sphingomyelin catabolic process	ISO	J:164563
Biological Process	GO:0006685	sphingomyelin catabolic process	IBA	J:265628
Biological Process	GO:0006685	sphingomyelin catabolic process	IMP	J:204092
Biological Process	GO:0023021	termination of signal transduction	ISO	J:164563
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563
Biological Process	GO:0042060	wound healing	ISO	J:164563