GO Annotations Graph

• Symbol: Ppia
• Name: peptidylprolyl isomerase A
• ID: MGI:97749

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016018	cyclosporin A binding	ISO	J:164563
Molecular Function	GO:0016018	cyclosporin A binding	ISO	J:155856
Molecular Function	GO:0016018	cyclosporin A binding	IBA	J:265628
Molecular Function	GO:1904399	heparan sulfate binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IDA	J:292533
Molecular Function	GO:0016853	isomerase activity	IEA	J:60000
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IMP	J:292533
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	ISO	J:164563
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:292536
Molecular Function	GO:0005515	protein binding	IPI	J:110552
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:287816
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0060352	cell adhesion molecule production	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0042118	endothelial cell activation	ISO	J:164563
Biological Process	GO:0030595	leukocyte chemotaxis	ISO	J:164563
Biological Process	GO:0034389	lipid droplet organization	ISO	J:164563
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0061944	negative regulation of protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0032873	negative regulation of stress-activated MAPK cascade	ISO	J:164563
Biological Process	GO:1903901	negative regulation of viral life cycle	ISO	J:164563
Biological Process	GO:0030182	neuron differentiation	IMP	J:110552
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0030168	platelet activation	IMP	J:292533
Biological Process	GO:0070527	platelet aggregation	IMP	J:292533
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0035307	positive regulation of protein dephosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0045070	positive regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0006457	protein folding	IBA	J:265628
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	ISO	J:164563
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	IBA	J:265628
Biological Process	GO:2001233	regulation of apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0045069	regulation of viral genome replication	ISO	J:164563