GO Annotations Graph

• Symbol: Il1a
• Name: interleukin 1 alpha
• ID: MGI:96542

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005507	copper ion binding	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	ISO	J:164563
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	IDA	J:193599
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:168000
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0034605	cellular response to heat	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IBA	J:265628
Biological Process	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	IMP	J:107475
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IGI	J:115619
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:115619
Biological Process	GO:0001660	fever generation	IEA	J:60000
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0072639	interleukin-33 production	IDA	J:301363
Biological Process	GO:0006883	intracellular sodium ion homeostasis	IDA	J:155496
Biological Process	GO:0031424	keratinization	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1904445	negative regulation of establishment of Sertoli cell barrier	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:82394
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	IBA	J:265628
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:1902624	positive regulation of neutrophil migration	ISO	J:155856
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	ISO	J:155856
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0010893	positive regulation of steroid biosynthetic process	ISO	J:155856
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:151963
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	IMP	J:82394
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	IBA	J:265628
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0046688	response to copper ion	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IDA	J:193599