GO Annotations Graph

• Symbol: Icam1
• Name: intercellular adhesion molecule 1
• ID: MGI:96392

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005178	integrin binding	ISO	J:155856
Molecular Function	GO:0005178	integrin binding	ISO	J:164563
Molecular Function	GO:0005178	integrin binding	IBA	J:265628
Molecular Function	GO:0005178	integrin binding	ISO	J:200103
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:140121
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0001772	immunological synapse	IDA	J:322366
Cellular Component	GO:0001772	immunological synapse	IDA	J:89097
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	IDA	J:215657
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	ISO	J:155856
Biological Process	GO:0044406	adhesion of symbiont to host	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IBA	J:265628
Biological Process	GO:0007155	cell adhesion	IDA	J:91862
Biological Process	GO:0007155	cell adhesion	IDA	J:83226
Biological Process	GO:0033627	cell adhesion mediated by integrin	IDA	J:125134
Biological Process	GO:0098609	cell-cell adhesion	ISO	J:155856
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:0071333	cellular response to glucose stimulus	IDA	J:126723
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	ISO	J:155856
Biological Process	GO:0097368	establishment of Sertoli cell barrier	ISO	J:155856
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ISO	J:164563
Biological Process	GO:0007159	leukocyte cell-cell adhesion	IMP	J:125139
Biological Process	GO:0051926	negative regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:155856
Biological Process	GO:0002693	positive regulation of cellular extravasation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:155856
Biological Process	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	ISO	J:155856
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:155856
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0046813	receptor-mediated virion attachment to host cell	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	ISO	J:155856
Biological Process	GO:1900027	regulation of ruffle assembly	IDA	J:195919
Biological Process	GO:0007605	sensory perception of sound	ISO	J:155856
Biological Process	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISO	J:164563
Biological Process	GO:0002457	T cell antigen processing and presentation	IDA	J:10119
Biological Process	GO:0072683	T cell extravasation	IMP	J:145418