GO Annotations Graph

• Symbol: Hspb1
• Name: heat shock protein 1
• ID: MGI:96240

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0044183	protein folding chaperone	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0005080	protein kinase C binding	IDA	J:99082
Molecular Function	GO:0008426	protein kinase C inhibitor activity	IDA	J:99082
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0097512	cardiac myofibril	ISO	J:155856
Cellular Component	GO:0043292	contractile fiber	IDA	J:87935
Cellular Component	GO:0001533	cornified envelope	IDA	J:230728
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:73470
Cellular Component	GO:0005737	cytoplasm	IDA	J:220288
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0031674	I band	ISO	J:155856
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:39331
Cellular Component	GO:0031430	M band	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:73470
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:87935
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0000502	proteasome complex	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IDA	J:87935
Biological Process	GO:0099641	anterograde axonal protein transport	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:0061077	chaperone-mediated protein folding	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	IDA	J:99082
Biological Process	GO:1903202	negative regulation of oxidative stress-induced cell death	ISO	J:155856
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA	J:99082
Biological Process	GO:0006469	negative regulation of protein kinase activity	IDA	J:99082
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	ISO	J:155856
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:2001028	positive regulation of endothelial cell chemotaxis	ISO	J:164563
Biological Process	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	IDA	J:173748
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IDA	J:173748
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	IDA	J:173748
Biological Process	GO:0001932	regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0006986	response to unfolded protein	NAS	J:172909