GO Annotations Graph

• Symbol: Fth1
• Name: ferritin heavy polypeptide 1
• ID: MGI:95588

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008199	ferric iron binding	IBA	J:265628
Molecular Function	GO:0008198	ferrous iron binding	IBA	J:265628
Molecular Function	GO:0004322	ferroxidase activity	IEA	J:72245
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:314371
Molecular Function	GO:0042802	identical protein binding	IPI	J:314564
Molecular Function	GO:0042802	identical protein binding	IPI	J:103507
Molecular Function	GO:0005506	iron ion binding	IDA	J:176157
Molecular Function	GO:0140315	iron ion sequestering activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Cellular Component	GO:0044754	autolysosome	ISO	J:217701
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0071682	endocytic vesicle lumen	TAS	Reactome:R-MMU-2507848
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2187267
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2507848
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Biological Process	GO:0006879	intracellular iron ion homeostasis	IEA	J:72247
Biological Process	GO:0006879	intracellular iron ion homeostasis	IEA	J:60000
Biological Process	GO:0006880	intracellular sequestering of iron ion	IBA	J:265628
Biological Process	GO:0006826	iron ion transport	IBA	J:265628
Biological Process	GO:0006826	iron ion transport	IDA	J:176157
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0060547	negative regulation of necrotic cell death	ISO	J:155856