GO Annotations Graph

• Symbol: Fgf4
• Name: fibroblast growth factor 4
• ID: MGI:95518

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:13170
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Biological Process	GO:0009887	animal organ morphogenesis	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IGI	J:102854
Biological Process	GO:0006915	apoptotic process	IGI	J:102854
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	IGI	J:96501
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	IGI	J:96501
Biological Process	GO:0001502	cartilage condensation	IGI	J:30824
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0008283	cell population proliferation	IGI	J:102854
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0060591	chondroblast differentiation	ISO	J:164563
Biological Process	GO:0060363	cranial suture morphogenesis	IDA	J:47321
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	IGI	J:102854
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:93163
Biological Process	GO:1904019	epithelial cell apoptotic process	IGI	J:96501
Biological Process	GO:1904019	epithelial cell apoptotic process	IGI	J:96501
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ISO	J:73065
Biological Process	GO:0010463	mesenchymal cell proliferation	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:102854
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IDA	J:80990
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:73065
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:127453
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:41974
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IBA	J:265628
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:148987
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IGI	J:102854
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:47321
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:36231
Biological Process	GO:0030334	regulation of cell migration	IBA	J:265628
Biological Process	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IDA	J:148987
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:92446
Biological Process	GO:0019827	stem cell population maintenance	IGI	J:92446
Biological Process	GO:0072089	stem cell proliferation	IGI	J:102854