GO Annotations Graph

• Symbol: Fech
• Name: ferrochelatase
• ID: MGI:95513

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0004325	ferrochelatase activity	ISO	J:155856
Molecular Function	GO:0004325	ferrochelatase activity	ISO	J:164563
Molecular Function	GO:0004325	ferrochelatase activity	IBA	J:265628
Molecular Function	GO:0004325	ferrochelatase activity	IMP	J:52058
Molecular Function	GO:0004325	ferrochelatase activity	IMP	J:141509
Molecular Function	GO:0004325	ferrochelatase activity	IDA	J:107071
Molecular Function	GO:0004325	ferrochelatase activity	IMP	J:135776
Molecular Function	GO:0004325	ferrochelatase activity	IDA	J:117517
Molecular Function	GO:0004325	ferrochelatase activity	IMP	J:12757
Molecular Function	GO:0004325	ferrochelatase activity	IDA	J:89825
Molecular Function	GO:0004325	ferrochelatase activity	ISO	J:37352
Molecular Function	GO:0004325	ferrochelatase activity	IDA	J:107071
Molecular Function	GO:0004325	ferrochelatase activity	IDA	J:78345
Molecular Function	GO:0020037	heme binding	IDA	J:107071
Molecular Function	GO:0005506	iron ion binding	IDA	J:89825
Molecular Function	GO:0030350	iron-responsive element binding	IDA	J:28927
Molecular Function	GO:0051536	iron-sulfur cluster binding	IEA	J:60000
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:304585
Molecular Function	GO:0005515	protein binding	IPI	J:162800
Molecular Function	GO:0005515	protein binding	IPI	J:236913
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0046906	tetrapyrrole binding	IDA	J:107071
Molecular Function	GO:0046906	tetrapyrrole binding	IDA	J:107071
Molecular Function	GO:0046906	tetrapyrrole binding	IDA	J:117517
Molecular Function	GO:0046906	tetrapyrrole binding	IDA	J:89825
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:236913
Cellular Component	GO:0005743	mitochondrial inner membrane	TAS	J:78345
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:67180
Biological Process	GO:0009589	detection of UV	IMP	J:78345
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:2021
Biological Process	GO:0006783	heme biosynthetic process	ISO	J:155856
Biological Process	GO:0006783	heme biosynthetic process	ISO	J:164563
Biological Process	GO:0006783	heme biosynthetic process	IBA	J:265628
Biological Process	GO:0006783	heme biosynthetic process	IDA	J:107071
Biological Process	GO:0006783	heme biosynthetic process	IMP	J:52058
Biological Process	GO:0006783	heme biosynthetic process	IDA	J:117517
Biological Process	GO:0006783	heme biosynthetic process	IMP	J:135776
Biological Process	GO:0006783	heme biosynthetic process	IMP	J:31650
Biological Process	GO:0006783	heme biosynthetic process	TAS	J:78345
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	IMP	J:141509
Biological Process	GO:0006779	porphyrin-containing compound biosynthetic process	IMP	J:78345
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	ISO	J:164563
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	IGI	J:99200
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	IGI	J:99200
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	IGI	J:99200
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	IMP	J:99200
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	IGI	J:99200
Biological Process	GO:0010468	regulation of gene expression	IMP	J:203507
Biological Process	GO:0046984	regulation of hemoglobin biosynthetic process	IGI	J:99200
Biological Process	GO:0046984	regulation of hemoglobin biosynthetic process	IGI	J:99200
Biological Process	GO:0009416	response to light stimulus	IMP	J:2021
Biological Process	GO:0034379	very-low-density lipoprotein particle assembly	IMP	J:67180