GO Annotations Graph

• Symbol: Eif2s1
• Name: eukaryotic translation initiation factor 2, subunit 1 alpha
• ID: MGI:95299

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:200502
Molecular Function	GO:0005515	protein binding	IPI	J:93997
Molecular Function	GO:0043022	ribosome binding	ISO	J:164563
Molecular Function	GO:0043022	ribosome binding	IBA	J:265628
Molecular Function	GO:0003723	RNA binding	IEA	J:72247
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0003743	translation initiation factor activity	ISO	J:164563
Molecular Function	GO:0003743	translation initiation factor activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:82058
Cellular Component	GO:0010494	cytoplasmic stress granule	IDA	J:162904
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9655565
Cellular Component	GO:0033290	eukaryotic 48S preinitiation complex	IBA	J:265628
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	ISO	J:164563
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	ISO	J:155856
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	IBA	J:265628
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	ISO	J:164563
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	IBA	J:265628
Cellular Component	GO:0097451	glial limiting end-foot	ISO	J:155856
Cellular Component	GO:0043614	multi-eIF complex	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:82058
Cellular Component	GO:0045202	synapse	EXP	J:263419
Cellular Component	GO:0045202	synapse	IDA	J:263419
Cellular Component	GO:0045202	synapse	EXP	J:263376
Cellular Component	GO:0045202	synapse	IDA	J:263376
Cellular Component	GO:0044207	translation initiation ternary complex	ISO	J:155856
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0034198	cellular response to amino acid starvation	IDA	J:99455
Biological Process	GO:0034605	cellular response to heat	ISO	J:155856
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:259116
Biological Process	GO:0034644	cellular response to UV	IDA	J:227395
Biological Process	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	ISO	J:155856
Biological Process	GO:0032057	negative regulation of translational initiation in response to stress	IDA	J:227395
Biological Process	GO:0036499	PERK-mediated unfolded protein response	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:164563
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	IDA	J:146172
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0043558	regulation of translational initiation in response to stress	IDA	J:100824
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:99455
Biological Process	GO:0034063	stress granule assembly	IMP	J:259116
Biological Process	GO:0006412	translation	IDA	J:62257
Biological Process	GO:0006412	translation	IDA	J:107108
Biological Process	GO:0006412	translation	IDA	J:82058
Biological Process	GO:0006413	translational initiation	ISO	J:164563