GO Annotations Graph

• Symbol: Csk
• Name: c-src tyrosine kinase
• ID: MGI:88537

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	TAS	J:113969
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0070064	proline-rich region binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:276512
Molecular Function	GO:0005515	protein binding	IPI	J:239186
Molecular Function	GO:0005515	protein binding	IPI	J:239190
Molecular Function	GO:0005515	protein binding	IPI	J:113969
Molecular Function	GO:0005515	protein binding	IPI	J:208677
Molecular Function	GO:0005515	protein binding	IPI	J:98324
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	TAS	J:113969
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISS	J:227393
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	TAS	J:113969
Cellular Component	GO:0005911	cell-cell junction	IDA	J:98324
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	J:113969
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0034332	adherens junction organization	IBA	J:265628
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	ISO	J:155856
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0035556	intracellular signal transduction	TAS	J:113969
Biological Process	GO:0045779	negative regulation of bone resorption	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:98324
Biological Process	GO:0008285	negative regulation of cell population proliferation	IGI	J:98324
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0042997	negative regulation of Golgi to plasma membrane protein transport	ISO	J:164563
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0033673	negative regulation of kinase activity	ISO	J:155856
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	ISO	J:155856
Biological Process	GO:0050765	negative regulation of phagocytosis	ISO	J:155856
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	TAS	J:113969
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	ISO	J:155856
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	IBA	J:265628
Biological Process	GO:0050863	regulation of T cell activation	TAS	J:113969