GO Annotations Graph

• Symbol: Col2a1
• Name: collagen, type II, alpha 1
• ID: MGI:88452

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005201	extracellular matrix structural constituent	IBA	J:265628
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	RCA	J:265607
Molecular Function	GO:0042802	identical protein binding	IPI	J:184499
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0042289	MHC class II protein binding	ISO	J:164563
Molecular Function	GO:0048407	platelet-derived growth factor binding	ISO	J:73065
Molecular Function	GO:0043394	proteoglycan binding	ISO	J:255711
Cellular Component	GO:0005604	basement membrane	IDA	J:68440
Cellular Component	GO:0005581	collagen trimer	IDA	J:128357
Cellular Component	GO:0005581	collagen trimer	IDA	J:166870
Cellular Component	GO:0005585	collagen type II trimer	ISO	J:164563
Cellular Component	GO:0005585	collagen type II trimer	IBA	J:265628
Cellular Component	GO:0005585	collagen type II trimer	IDA	J:52896
Cellular Component	GO:0005585	collagen type II trimer	IMP	J:6582
Cellular Component	GO:0005585	collagen type II trimer	IDA	J:52896
Cellular Component	GO:0005592	collagen type XI trimer	NAS	J:320087
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:155856
Cellular Component	GO:0062023	collagen-containing extracellular matrix	NAS	J:320087
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:87774
Cellular Component	GO:0005737	cytoplasm	IDA	J:84742
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0031012	extracellular matrix	IDA	J:32201
Cellular Component	GO:0031012	extracellular matrix	IDA	J:214169
Cellular Component	GO:0031012	extracellular matrix	IDA	J:174146
Cellular Component	GO:0031012	extracellular matrix	IDA	J:128547
Cellular Component	GO:0031012	extracellular matrix	IDA	J:182341
Cellular Component	GO:0031012	extracellular matrix	IDA	J:45403
Cellular Component	GO:0031012	extracellular matrix	IDA	J:45403
Cellular Component	GO:0031012	extracellular matrix	IDA	J:202984
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:84742
Cellular Component	GO:0005615	extracellular space	IDA	J:87774
Biological Process	GO:0097065	anterior head development	IMP	J:223062
Biological Process	GO:0097065	anterior head development	IMP	J:223062
Biological Process	GO:0060348	bone development	IMP	J:68674
Biological Process	GO:0060348	bone development	IMP	J:68674
Biological Process	GO:0001502	cartilage condensation	IMP	J:83918
Biological Process	GO:0051216	cartilage development	IMP	J:30041
Biological Process	GO:0051216	cartilage development	IMP	J:106329
Biological Process	GO:0051216	cartilage development	IMP	J:30041
Biological Process	GO:0051216	cartilage development	IMP	J:51376
Biological Process	GO:0051216	cartilage development	IMP	J:39102
Biological Process	GO:0051216	cartilage development	IMP	J:117910
Biological Process	GO:0051216	cartilage development	IMP	J:40841
Biological Process	GO:0051216	cartilage development	IMP	J:54161
Biological Process	GO:0051216	cartilage development	IMP	J:6582
Biological Process	GO:0051216	cartilage development	IMP	J:54161
Biological Process	GO:0051216	cartilage development	IMP	J:51376
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IMP	J:37522
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IMP	J:38204
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IMP	J:117910
Biological Process	GO:0071773	cellular response to BMP stimulus	IDA	J:164076
Biological Process	GO:0007417	central nervous system development	IEP	J:38926
Biological Process	GO:0002062	chondrocyte differentiation	IEP	J:38926
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:117910
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:30041
Biological Process	GO:0030199	collagen fibril organization	ISO	J:164563
Biological Process	GO:0030199	collagen fibril organization	IBA	J:265628
Biological Process	GO:0030199	collagen fibril organization	IMP	J:51968
Biological Process	GO:0030199	collagen fibril organization	IMP	J:106329
Biological Process	GO:0030199	collagen fibril organization	IMP	J:83918
Biological Process	GO:0030199	collagen fibril organization	IMP	J:30041
Biological Process	GO:0030199	collagen fibril organization	IMP	J:6582
Biological Process	GO:0030199	collagen fibril organization	IMP	J:51376
Biological Process	GO:0030199	collagen fibril organization	IMP	J:37522
Biological Process	GO:0030199	collagen fibril organization	IMP	J:38204
Biological Process	GO:0060272	embryonic skeletal joint morphogenesis	ISO	J:164563
Biological Process	GO:0001958	endochondral ossification	IMP	J:54161
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:43079
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:43079
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:43079
Biological Process	GO:0003007	heart morphogenesis	IMP	J:30041
Biological Process	GO:0048839	inner ear development	IMP	J:54161
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:40841
Biological Process	GO:0060174	limb bud formation	IEP	J:175328
Biological Process	GO:0035108	limb morphogenesis	IMP	J:54161
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:43079
Biological Process	GO:0030903	notochord development	IEP	J:38926
Biological Process	GO:0030903	notochord development	IBA	J:265628
Biological Process	GO:0001503	ossification	IEP	J:38926
Biological Process	GO:0071599	otic vesicle development	IEP	J:38926
Biological Process	GO:0006029	proteoglycan metabolic process	IMP	J:6582
Biological Process	GO:0006029	proteoglycan metabolic process	IMP	J:83918
Biological Process	GO:0010468	regulation of gene expression	IMP	J:43079
Biological Process	GO:0060021	roof of mouth development	IMP	J:6582
Biological Process	GO:0007605	sensory perception of sound	ISO	J:164563
Biological Process	GO:0001501	skeletal system development	ISO	J:164563
Biological Process	GO:0001501	skeletal system development	IBA	J:265628
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:17182
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:51968
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:30041
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:6582
Biological Process	GO:0001894	tissue homeostasis	IMP	J:115506
Biological Process	GO:0007601	visual perception	ISO	J:164563