Cd28 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cd28
CD28 antigen
MGI:88327

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IPI	J:170513
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:205441
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:17350
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:26220
Cellular Component	GO:0009897	external side of plasma membrane	IMP	J:14194
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:142709
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:73065
Cellular Component	GO:0001772	immunological synapse	IDA	J:205441
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:73065
Cellular Component	GO:0098636	protein complex involved in cell adhesion	ISO	J:28279
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:56164
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IMP	J:125135
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IDA	J:89097
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IDA	J:17350
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IDA	J:125135
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0032623	interleukin-2 production	IMP	J:14194
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045060	negative thymic T cell selection	IMP	J:56164
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	IDA	J:202549
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA	J:125135
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA	J:17350
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA	J:89097
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP	J:125135
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0002863	positive regulation of inflammatory response to antigenic stimulus	IMP	J:120498
Biological Process	GO:0032733	positive regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IMP	J:14194
Biological Process	GO:0032753	positive regulation of interleukin-4 production	ISO	J:164563
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IMP	J:14194
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IDA	J:202549
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:202549
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	IBA	J:265628
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:89322
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:91914
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:14194
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:84973
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:120498
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:139460
Biological Process	GO:0043491	protein kinase B signaling	IDA	J:202549
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	IGI	J:170513
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	IGI	J:170513
Biological Process	GO:0042129	regulation of T cell proliferation	IEA	J:72247
Biological Process	GO:0045066	regulatory T cell differentiation	ISO	J:164563
Biological Process	GO:0042110	T cell activation	ISO	J:164563
Biological Process	GO:0042110	T cell activation	ISO	J:155856
Biological Process	GO:0042110	T cell activation	IBA	J:265628
Biological Process	GO:0031295	T cell costimulation	ISO	J:155856
Biological Process	GO:0031295	T cell costimulation	IBA	J:265628
Biological Process	GO:0031295	T cell costimulation	IDA	J:125135
Biological Process	GO:0031295	T cell costimulation	IDA	J:17350
Biological Process	GO:0031295	T cell costimulation	IMP	J:125135
Biological Process	GO:0031295	T cell costimulation	IDA	J:91914
Biological Process	GO:0031295	T cell costimulation	IGI	J:205441
Biological Process	GO:0031295	T cell costimulation	IMP	J:14194
Biological Process	GO:0031295	T cell costimulation	IDA	J:56164
Biological Process	GO:0031295	T cell costimulation	IDA	J:84973
Biological Process	GO:0042098	T cell proliferation	IMP	J:120498
Biological Process	GO:0042098	T cell proliferation	IMP	J:14194
Biological Process	GO:0042098	T cell proliferation	IDA	J:91914
Biological Process	GO:0042098	T cell proliferation	IDA	J:84973
Biological Process	GO:0050852	T cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:205441
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:139460

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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