GO Annotations Graph

• Symbol: Ank2
• Name: ankyrin 2, brain
• ID: MGI:88025

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051117	ATPase binding	IPI	J:103813
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0140031	phosphorylation-dependent protein binding	ISO	J:164563
Molecular Function	GO:0015459	potassium channel regulator activity	IMP	J:166301
Molecular Function	GO:0005515	protein binding	IPI	J:153221
Molecular Function	GO:0005515	protein binding	IPI	J:175049
Molecular Function	GO:0005515	protein binding	IPI	J:175049
Molecular Function	GO:0005515	protein binding	IPI	J:126030
Molecular Function	GO:0005515	protein binding	IPI	J:93341
Molecular Function	GO:0005515	protein binding	IPI	J:93347
Molecular Function	GO:0005515	protein binding	IPI	J:175049
Molecular Function	GO:0005515	protein binding	IPI	J:175049
Molecular Function	GO:0005515	protein binding	IPI	J:166301
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IMP	J:166301
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IDA	J:103813
Molecular Function	GO:0030507	spectrin binding	ISO	J:164563
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ISO	J:155856
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:166301
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:103813
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Cellular Component	GO:0031672	A band	IDA	J:75468
Cellular Component	GO:0031672	A band	IDA	J:103813
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0043034	costamere	IDA	J:103813
Cellular Component	GO:0005737	cytoplasm	IDA	J:93347
Cellular Component	GO:0005856	cytoskeleton	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IDA	J:145566
Cellular Component	GO:0014704	intercalated disc	IDA	J:81699
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0031430	M band	IDA	J:81699
Cellular Component	GO:0031430	M band	IDA	J:143121
Cellular Component	GO:0031430	M band	IDA	J:93347
Cellular Component	GO:0031430	M band	IMP	J:185021
Cellular Component	GO:0031430	M band	IDA	J:126030
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0033010	paranodal junction	IDA	J:108683
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:175049
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IMP	J:186061
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	NAS	J:186068
Cellular Component	GO:0005886	plasma membrane	IDA	J:175049
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0045211	postsynaptic membrane	IEA	J:60000
Cellular Component	GO:0042383	sarcolemma	IMP	J:185021
Cellular Component	GO:0042383	sarcolemma	IDA	J:103813
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0030315	T-tubule	IDA	J:103813
Cellular Component	GO:0030315	T-tubule	IDA	J:81699
Cellular Component	GO:0030315	T-tubule	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:127606
Cellular Component	GO:0030018	Z disc	IDA	J:75468
Cellular Component	GO:0030018	Z disc	IDA	J:81699
Cellular Component	GO:0030018	Z disc	IDA	J:126030
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0086014	atrial cardiac muscle cell action potential	IMP	J:185021
Biological Process	GO:0086066	atrial cardiac muscle cell to AV node cell communication	IMP	J:81699
Biological Process	GO:0003283	atrial septum development	ISO	J:164563
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:93347
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:186061
Biological Process	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	IMP	J:186061
Biological Process	GO:0051928	positive regulation of calcium ion transport	IMP	J:186061
Biological Process	GO:2001259	positive regulation of cation channel activity	IMP	J:153221
Biological Process	GO:2001259	positive regulation of cation channel activity	IMP	J:166301
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:130154
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:186061
Biological Process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	IMP	J:166301
Biological Process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	IMP	J:153221
Biological Process	GO:0043268	positive regulation of potassium ion transport	IMP	J:153221
Biological Process	GO:0043268	positive regulation of potassium ion transport	IMP	J:166301
Biological Process	GO:0008104	protein localization	IMP	J:130154
Biological Process	GO:0008104	protein localization	ISO	J:164563
Biological Process	GO:0008104	protein localization	IMP	J:126030
Biological Process	GO:0008104	protein localization	IMP	J:93347
Biological Process	GO:0034394	protein localization to cell surface	IMP	J:93347
Biological Process	GO:0070972	protein localization to endoplasmic reticulum	IMP	J:75468
Biological Process	GO:0070972	protein localization to endoplasmic reticulum	ISO	J:164563
Biological Process	GO:0070972	protein localization to endoplasmic reticulum	IMP	J:90861
Biological Process	GO:0036309	protein localization to M-band	IMP	J:93347
Biological Process	GO:0036309	protein localization to M-band	IMP	J:143121
Biological Process	GO:0033365	protein localization to organelle	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:153221
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:185021
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:186061
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:175049
Biological Process	GO:0072659	protein localization to plasma membrane	IGI	J:175049
Biological Process	GO:0072659	protein localization to plasma membrane	IMP	J:166301
Biological Process	GO:0036371	protein localization to T-tubule	IMP	J:103813
Biological Process	GO:0036371	protein localization to T-tubule	IBA	J:265628
Biological Process	GO:0050821	protein stabilization	IMP	J:186068
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0042981	regulation of apoptotic process	RCA	J:84168
Biological Process	GO:0098910	regulation of atrial cardiac muscle cell action potential	ISO	J:164563
Biological Process	GO:0098910	regulation of atrial cardiac muscle cell action potential	IMP	J:81699
Biological Process	GO:0098904	regulation of AV node cell action potential	IMP	J:81699
Biological Process	GO:1901019	regulation of calcium ion transmembrane transporter activity	IMP	J:185021
Biological Process	GO:0051924	regulation of calcium ion transport	IMP	J:81699
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0051924	regulation of calcium ion transport	IMP	J:90861
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	IMP	J:130154
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ISO	J:164563
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	IGI	J:175049
Biological Process	GO:0086036	regulation of cardiac muscle cell membrane potential	IMP	J:175049
Biological Process	GO:0055117	regulation of cardiac muscle contraction	IMP	J:90861
Biological Process	GO:0055117	regulation of cardiac muscle contraction	ISO	J:164563
Biological Process	GO:0055117	regulation of cardiac muscle contraction	IBA	J:265628
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	IMP	J:81699
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	ISO	J:164563
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISO	J:164563
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IC	J:81699
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IMP	J:185021
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IMP	J:186068
Biological Process	GO:2001257	regulation of cation channel activity	IMP	J:166301
Biological Process	GO:0002027	regulation of heart rate	ISO	J:164563
Biological Process	GO:0002027	regulation of heart rate	IMP	J:186061
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:75468
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:90861
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:81699
Biological Process	GO:0031647	regulation of protein stability	IC	J:186061
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0098907	regulation of SA node cell action potential	IMP	J:81699
Biological Process	GO:0098907	regulation of SA node cell action potential	ISO	J:164563
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	ISO	J:164563
Biological Process	GO:0086015	SA node cell action potential	IMP	J:186061
Biological Process	GO:0086070	SA node cell to atrial cardiac muscle cell communication	ISO	J:164563
Biological Process	GO:0086070	SA node cell to atrial cardiac muscle cell communication	IMP	J:186061
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0033292	T-tubule organization	IMP	J:103813
Biological Process	GO:0033292	T-tubule organization	IMP	J:166301
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	ISO	J:164563