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GO Annotations Graph
Symbol
Name
ID
Grk2
G protein-coupled receptor kinase 2
MGI:87940

GO annotations  (Text View)    (Tabular View)

A table of the annotations represented in this image is provided below.
CategoryGO IDClassification TermEvidenceReference
Molecular FunctionGO:0005524ATP bindingIEAJ:72247
Molecular FunctionGO:0005524ATP bindingIEAJ:60000
Molecular FunctionGO:0047696beta-adrenergic receptor kinase activityISOJ:155856
Molecular FunctionGO:0031755Edg-2 lysophosphatidic acid receptor bindingISOJ:164563
Molecular FunctionGO:0004703G-protein coupled receptor kinase activityISOJ:155856
Molecular FunctionGO:0004703G-protein coupled receptor kinase activityIDAJ:88364
Molecular FunctionGO:0004703G-protein coupled receptor kinase activityIMPJ:36567
Molecular FunctionGO:0004703G-protein coupled receptor kinase activityIDAJ:11373
Molecular FunctionGO:0016301kinase activityIEAJ:60000
Molecular FunctionGO:0000166nucleotide bindingIEAJ:60000
Molecular FunctionGO:0005515protein bindingIPIJ:105642
Molecular FunctionGO:0005515protein bindingIPIJ:122283
Molecular FunctionGO:0004672protein kinase activityIDAJ:105642
Molecular FunctionGO:0004674protein serine/threonine kinase activityIDAJ:122283
Molecular FunctionGO:0016740transferase activityIEAJ:60000
Cellular ComponentGO:0016324apical plasma membraneISOJ:155856
Cellular ComponentGO:0030424axonISOJ:155856
Cellular ComponentGO:0016323basolateral plasma membraneISOJ:155856
Cellular ComponentGO:0005901caveolaISOJ:155856
Cellular ComponentGO:0005737cytoplasmISOJ:164563
Cellular ComponentGO:0005737cytoplasmISOJ:155856
Cellular ComponentGO:0043198dendritic shaftISOJ:155856
Cellular ComponentGO:0043197dendritic spineISOJ:155856
Cellular ComponentGO:0016020membraneISOJ:164563
Cellular ComponentGO:0016020membraneIDAJ:105642
Cellular ComponentGO:0005886plasma membraneIEAJ:60000
Cellular ComponentGO:0045202synapseISOJ:155856
Biological ProcessGO:0060048cardiac muscle contractionISOJ:164563
Biological ProcessGO:0002029desensitization of G-protein coupled receptor protein signaling pathwayISOJ:155856
Biological ProcessGO:0002029desensitization of G-protein coupled receptor protein signaling pathwayIMPJ:55312
Biological ProcessGO:0002029desensitization of G-protein coupled receptor protein signaling pathwayIGIJ:37034
Biological ProcessGO:0042699follicle-stimulating hormone signaling pathwayISOJ:155856
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayISOJ:155856
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayIDAJ:88364
Biological ProcessGO:0007507heart developmentIMPJ:36567
Biological ProcessGO:0045744negative regulation of G-protein coupled receptor protein signaling pathwayISOJ:155856
Biological ProcessGO:0045988negative regulation of striated muscle contractionISOJ:164563
Biological ProcessGO:0003108negative regulation of the force of heart contraction by chemical signalISOJ:164563
Biological ProcessGO:0018105peptidyl-serine phosphorylationIDAJ:122283
Biological ProcessGO:0018107peptidyl-threonine phosphorylationIDAJ:122283
Biological ProcessGO:0016310phosphorylationIEAJ:60000
Biological ProcessGO:0033605positive regulation of catecholamine secretionISOJ:155856
Biological ProcessGO:0006468protein phosphorylationIDAJ:105642
Biological ProcessGO:0006468protein phosphorylationISOJ:155856
Biological ProcessGO:0031623receptor internalizationISOJ:164563
Biological ProcessGO:0002026regulation of the force of heart contractionIGIJ:37034
Biological ProcessGO:0014070response to organic cyclic compoundISOJ:155856
Biological ProcessGO:0006979response to oxidative stressISOJ:155856
Biological ProcessGO:0007165signal transductionIEAJ:72247
Biological ProcessGO:0007217tachykinin receptor signaling pathwayISOJ:164563
Biological ProcessGO:0046718viral entry into host cellISOJ:164563
Biological ProcessGO:0019079viral genome replicationISOJ:164563


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/31/2023
MGI 6.22
The Jackson Laboratory