GO Annotations Graph

• Symbol: Kdm6b
• Name: KDM1 lysine (K)-specific demethylase 6B
• ID: MGI:2448492

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008013	beta-catenin binding	IPI	J:211228
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0031490	chromatin DNA binding	IBA	J:265628
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	ISO	J:164563
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	IDA	J:211228
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	IBA	J:265628
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	IMP	J:139680
Molecular Function	GO:0071558	histone H3K27me2/H3K27me3 demethylase activity	IMP	J:127720
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:166998
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:127720
Cellular Component	GO:0044666	MLL3/4 complex	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:211228
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:211228
Biological Process	GO:0045165	cell fate commitment	IMP	J:139680
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IDA	J:198334
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0006338	chromatin remodeling	IMP	J:166998
Biological Process	GO:0045446	endothelial cell differentiation	IMP	J:211228
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0021766	hippocampus development	ISO	J:155856
Biological Process	GO:0071557	histone H3-K27 demethylation	IDA	J:211228
Biological Process	GO:0071557	histone H3-K27 demethylation	IBA	J:265628
Biological Process	GO:0016570	histone modification	IMP	J:139680
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0048333	mesodermal cell differentiation	IMP	J:211228
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:227694
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:211228
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:127720
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:127720
Biological Process	GO:0010468	regulation of gene expression	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	IMP	J:139680