GO Annotations Graph

• Symbol: Nrros
• Name: negative regulator of reactive oxygen species
• ID: MGI:2445095

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019838	growth factor binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:209569
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	IPI	J:264027
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:264027
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:209569
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0006955	immune response	IMP	J:209569
Biological Process	GO:0006954	inflammatory response	IMP	J:209569
Biological Process	GO:0014005	microglia development	IMP	J:264027
Biological Process	GO:0014005	microglia development	IMP	J:257960
Biological Process	GO:0035583	sequestering of TGFbeta in extracellular matrix	IDA	J:264027
Biological Process	GO:0006801	superoxide metabolic process	IMP	J:209569
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:264027
Biological Process	GO:0036364	transforming growth factor beta1 activation	IDA	J:264027
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	TAS	J:209569