GO Annotations Graph

• Symbol: Htra2
• Name: HtrA serine peptidase 2
• ID: MGI:1928676

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	IEA	J:72247
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IMP	J:212461
Molecular Function	GO:0005515	protein binding	IPI	J:198601
Molecular Function	GO:0005515	protein binding	IPI	J:132627
Molecular Function	GO:0005515	protein binding	IPI	J:248249
Molecular Function	GO:0005515	protein binding	IPI	J:182411
Molecular Function	GO:0004252	serine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0008236	serine-type peptidase activity	ISO	J:164563
Molecular Function	GO:0008236	serine-type peptidase activity	ISO	J:155856
Cellular Component	GO:0035631	CD40 receptor complex	IDA	J:161997
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	IDA	J:161997
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:90428
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:205682
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:1905370	serine-type endopeptidase complex	ISO	J:164563
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:94227
Biological Process	GO:0007628	adult walking behavior	IMP	J:12780
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0034605	cellular response to heat	ISO	J:164563
Biological Process	GO:0035458	cellular response to interferon-beta	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:212461
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:164563
Biological Process	GO:0071300	cellular response to retinoic acid	ISO	J:164563
Biological Process	GO:0030900	forebrain development	IMP	J:94227
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	IMP	J:94227
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:164563
Biological Process	GO:0007005	mitochondrion organization	IMP	J:94277
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:155856
Biological Process	GO:1904924	negative regulation of mitophagy in response to mitochondrial depolarization	IMP	J:212461
Biological Process	GO:0048666	neuron development	IMP	J:12780
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:182411
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO	J:164563
Biological Process	GO:0010822	positive regulation of mitochondrion organization	ISO	J:164563
Biological Process	GO:0012501	programmed cell death	ISO	J:164563
Biological Process	GO:0012501	programmed cell death	IBA	J:265628
Biological Process	GO:0030163	protein catabolic process	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IMP	J:212461
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:94227
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:12780