GO Annotations Graph

• Symbol: Sirt2
• Name: sirtuin 2
• ID: MGI:1927664

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048487	beta-tubulin binding	IDA	J:194185
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0035035	histone acetyltransferase binding	ISO	J:164563
Molecular Function	GO:0004407	histone deacetylase activity	IMP	J:209463
Molecular Function	GO:0004407	histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051287	NAD binding	IEA	J:72247
Molecular Function	GO:0070403	NAD+ binding	ISO	J:164563
Molecular Function	GO:0070403	NAD+ binding	IBA	J:265628
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	IBA	J:265628
Molecular Function	GO:0046970	NAD-dependent histone H4K16 deacetylase activity	ISO	J:164563
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	ISO	J:164563
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	ISO	J:155856
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	ISO	J:164563
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:177486
Molecular Function	GO:0005515	protein binding	IPI	J:209483
Molecular Function	GO:0005515	protein binding	IPI	J:210910
Molecular Function	GO:0005515	protein binding	IPI	J:177486
Molecular Function	GO:0033558	protein lysine deacetylase activity	IMP	J:210910
Molecular Function	GO:0033558	protein lysine deacetylase activity	IMP	J:199358
Molecular Function	GO:0033558	protein lysine deacetylase activity	IMP	J:209483
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:164563
Molecular Function	GO:0033558	protein lysine deacetylase activity	IDA	J:129943
Molecular Function	GO:0008134	transcription factor binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0042903	tubulin deacetylase activity	ISO	J:155856
Molecular Function	GO:0042903	tubulin deacetylase activity	ISO	J:164563
Molecular Function	GO:0042903	tubulin deacetylase activity	IMP	J:209463
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005814	centriole	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005694	chromosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:209483
Cellular Component	GO:0005737	cytoplasm	IDA	J:210910
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	HDA	J:145263
Cellular Component	GO:0005737	cytoplasm	IDA	J:209463
Cellular Component	GO:0005737	cytoplasm	IDA	J:129943
Cellular Component	GO:0005737	cytoplasm	IDA	J:65632
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0097386	glial cell projection	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0000792	heterochromatin	ISO	J:155856
Cellular Component	GO:0044224	juxtaparanode region of axon	ISO	J:155856
Cellular Component	GO:0043219	lateral loop	ISO	J:155856
Cellular Component	GO:0072687	meiotic spindle	IDA	J:209463
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0030496	midbody	IDA	J:209463
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:233904
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0043209	myelin sheath	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0043209	myelin sheath	IDA	J:209487
Cellular Component	GO:0035748	myelin sheath abaxonal region	ISO	J:155856
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:209463
Cellular Component	GO:0005634	nucleus	IDA	J:209483
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0033010	paranodal junction	IDA	J:209487
Cellular Component	GO:0033010	paranodal junction	ISO	J:155856
Cellular Component	GO:0033270	paranode region of axon	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	IDA	J:209487
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:209487
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	ISO	J:155856
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	IDA	J:209487
Cellular Component	GO:0005819	spindle	ISO	J:164563
Cellular Component	GO:0097456	terminal loop	ISO	J:155856
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0044242	cellular lipid catabolic process	IMP	J:209483
Biological Process	GO:0061433	cellular response to caloric restriction	IDA	J:210910
Biological Process	GO:0071872	cellular response to epinephrine stimulus	IDA	J:209483
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:210910
Biological Process	GO:0006325	chromatin organization	IGI	J:162081
Biological Process	GO:0006325	chromatin organization	IGI	J:162081
Biological Process	GO:0040029	epigenetic regulation of gene expression	IMP	J:199358
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0070933	histone H4 deacetylation	ISO	J:164563
Biological Process	GO:0051321	meiotic cell cycle	IEA	J:60000
Biological Process	GO:0022011	myelination in peripheral nervous system	ISO	J:155856
Biological Process	GO:0022011	myelination in peripheral nervous system	IMP	J:177468
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:211313
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IMP	J:209483
Biological Process	GO:0045599	negative regulation of fat cell differentiation	IMP	J:129943
Biological Process	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly	IMP	J:196452
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0070446	negative regulation of oligodendrocyte progenitor proliferation	ISO	J:155856
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	IMP	J:177468
Biological Process	GO:0042177	negative regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	IMP	J:210910
Biological Process	GO:0045843	negative regulation of striated muscle tissue development	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:211313
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:209483
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:129943
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0044546	NLRP3 inflammasome complex assembly	IMP	J:196452
Biological Process	GO:0034983	peptidyl-lysine deacetylation	ISO	J:164563
Biological Process	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	IMP	J:209463
Biological Process	GO:0051781	positive regulation of cell division	IMP	J:209463
Biological Process	GO:0043388	positive regulation of DNA binding	IDA	J:210910
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	IMP	J:210910
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process	ISO	J:164563
Biological Process	GO:0045836	positive regulation of meiotic nuclear division	IMP	J:209463
Biological Process	GO:1900195	positive regulation of oocyte maturation	IMP	J:209463
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	J:211313
Biological Process	GO:2000777	positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:210910
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	IMP	J:209483
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	IMP	J:177468
Biological Process	GO:0006476	protein deacetylation	IDA	J:129943
Biological Process	GO:0006476	protein deacetylation	IMP	J:210910
Biological Process	GO:0006476	protein deacetylation	ISO	J:155856
Biological Process	GO:0006476	protein deacetylation	IMP	J:270211
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0045598	regulation of fat cell differentiation	IMP	J:193991
Biological Process	GO:0031641	regulation of myelination	ISO	J:155856
Biological Process	GO:0031641	regulation of myelination	IMP	J:177468
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	ISO	J:155856
Biological Process	GO:0090042	tubulin deacetylation	ISO	J:155856
Biological Process	GO:0090042	tubulin deacetylation	ISO	J:164563
Biological Process	GO:0090042	tubulin deacetylation	IGI	J:162081
Biological Process	GO:0090042	tubulin deacetylation	IGI	J:162081
Biological Process	GO:0090042	tubulin deacetylation	IMP	J:193991
Biological Process	GO:0090042	tubulin deacetylation	IMP	J:196452