GO Annotations Graph

• Symbol: Sost
• Name: sclerostin
• ID: MGI:1921749

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0036122	BMP binding	IBA	J:265628
Molecular Function	GO:0030246	carbohydrate binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	IEA	J:60000
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:218799
Molecular Function	GO:0005515	protein binding	IPI	J:128100
Molecular Function	GO:0005515	protein binding	IPI	J:128100
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0030509	BMP signaling pathway	IDA	J:128100
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:161416
Biological Process	GO:0071374	cellular response to parathyroid hormone stimulus	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IBA	J:265628
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	ISO	J:86838
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IDA	J:128100
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:161416
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:200671
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IDA	J:128100
Biological Process	GO:0001503	ossification	IBA	J:265628
Biological Process	GO:0001503	ossification	IDA	J:86838
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000