GO Annotations Graph

• Symbol: Actr3
• Name: ARP3 actin-related protein 3
• ID: MGI:1921367

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:155856
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0051117	ATPase binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:67836
Molecular Function	GO:0005515	protein binding	IPI	J:187581
Molecular Function	GO:0005515	protein binding	IPI	J:93351
Molecular Function	GO:0005515	protein binding	IPI	J:93351
Molecular Function	GO:0005200	structural constituent of cytoskeleton	ISO	J:164563
Cellular Component	GO:0005884	actin filament	ISO	J:155856
Cellular Component	GO:0061831	apical ectoplasmic specialization	ISO	J:155856
Cellular Component	GO:0061828	apical tubulobulbar complex	ISO	J:155856
Cellular Component	GO:0005885	Arp2/3 protein complex	ISO	J:164563
Cellular Component	GO:0005885	Arp2/3 protein complex	IBA	J:265628
Cellular Component	GO:0061832	basal ectoplasmic specialization	ISO	J:155856
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0031252	cell leading edge	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005911	cell-cell junction	ISO	J:155856
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0061830	concave side of sperm head	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0060076	excitatory synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0000139	Golgi membrane	ISO	J:155856
Cellular Component	GO:0030056	hemidesmosome	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IDA	J:87902
Cellular Component	GO:0061851	leading edge of lamellipodium	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0002102	podosome	ISO	J:155856
Cellular Component	GO:0061825	podosome core	ISO	J:155856
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0001726	ruffle	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	IEA	J:72247
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	ISO	J:164563
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation	IBA	J:265628
Biological Process	GO:0048708	astrocyte differentiation	ISO	J:155856
Biological Process	GO:0008356	asymmetric cell division	IGI	J:172280
Biological Process	GO:0030030	cell projection organization	IEA	J:60000
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:155856
Biological Process	GO:0071346	cellular response to type II interferon	IGI	J:143718
Biological Process	GO:0060271	cilium assembly	ISO	J:164563
Biological Process	GO:0007163	establishment or maintenance of cell polarity	IGI	J:172280
Biological Process	GO:0051321	meiotic cell cycle	IGI	J:172280
Biological Process	GO:0016344	meiotic chromosome movement towards spindle pole	IGI	J:195195
Biological Process	GO:0033206	meiotic cytokinesis	IGI	J:172280
Biological Process	GO:0030517	negative regulation of axon extension	ISO	J:155856
Biological Process	GO:1904171	negative regulation of bleb assembly	ISO	J:155856
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	ISO	J:155856
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:155856
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	ISO	J:155856
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	ISO	J:155856
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0010763	positive regulation of fibroblast migration	ISO	J:155856
Biological Process	GO:0051491	positive regulation of filopodium assembly	ISO	J:155856
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:155856
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:155856
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:155856
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	ISO	J:155856
Biological Process	GO:0051965	positive regulation of synapse assembly	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0099173	postsynapse organization	ISO	J:155856
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	ISO	J:155856
Biological Process	GO:0043519	regulation of myosin II filament organization	ISO	J:155856
Biological Process	GO:0051653	spindle localization	IGI	J:172280