GO Annotations Graph

• Symbol: Aifm2
• Name: apoptosis-inducing factor, mitochondrion-associated 2
• ID: MGI:1918611

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	ISO	J:164563
Molecular Function	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	IBA	J:265628
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:164563
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	IBA	J:265628
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:281212
Cellular Component	GO:0005737	cytoplasm	IDA	J:281212
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005811	lipid droplet	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:281212
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:281212
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0008637	apoptotic mitochondrial changes	IBA	J:265628
Biological Process	GO:0008637	apoptotic mitochondrial changes	ISO	J:73065
Biological Process	GO:1990748	cellular detoxification	ISO	J:164563
Biological Process	GO:0110076	negative regulation of ferroptosis	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	IBA	J:265628
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	IMP	J:281212
Biological Process	GO:0006743	ubiquinone metabolic process	ISO	J:164563
Biological Process	GO:0042373	vitamin K metabolic process	ISO	J:164563