GO Annotations Graph

• Symbol: Mul1
• Name: mitochondrial ubiquitin ligase activator of NFKB 1
• ID: MGI:1915600

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0019789	SUMO transferase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IBA	J:265628
Cellular Component	GO:0030424	axon	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0005777	peroxisome	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0071360	cellular response to exogenous dsRNA	ISO	J:164563
Biological Process	GO:0000266	mitochondrial fission	ISO	J:164563
Biological Process	GO:0051646	mitochondrion localization	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	ISO	J:164563
Biological Process	GO:0050689	negative regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:0045824	negative regulation of innate immune response	ISO	J:164563
Biological Process	GO:0010637	negative regulation of mitochondrial fusion	ISO	J:164563
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0006996	organelle organization	IEA	J:72247
Biological Process	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	IMP	J:212461
Biological Process	GO:1903861	positive regulation of dendrite extension	IMP	J:219122
Biological Process	GO:1903861	positive regulation of dendrite extension	IGI	J:219122
Biological Process	GO:0090141	positive regulation of mitochondrial fission	ISO	J:164563
Biological Process	GO:0033235	positive regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	IGI	J:219122
Biological Process	GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0010821	regulation of mitochondrion organization	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	IMP	J:219122