GO Annotations Graph

• Symbol: Sirt5
• Name: sirtuin 5
• ID: MGI:1915596

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0070403	NAD+ binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:148769
Molecular Function	GO:0061697	protein-glutaryllysine deglutarylase activity	IDA	J:213152
Molecular Function	GO:0061697	protein-glutaryllysine deglutarylase activity	ISO	J:164563
Molecular Function	GO:0036054	protein-malonyllysine demalonylase activity	IMP	J:180637
Molecular Function	GO:0036054	protein-malonyllysine demalonylase activity	ISO	J:164563
Molecular Function	GO:0036054	protein-malonyllysine demalonylase activity	IDA	J:213152
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	ISO	J:164563
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	IMP	J:203468
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	IDA	J:213152
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	IMP	J:180637
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	IMP	J:177830
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	IMP	J:205910
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	IBA	J:265628
Molecular Function	GO:0036055	protein-succinyllysine desuccinylase activity	IMP	J:251621
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:203468
Cellular Component	GO:0005743	mitochondrial inner membrane	IDA	J:130436
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:203468
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IDA	J:129009
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IMP	J:251621
Cellular Component	GO:0005739	mitochondrion	IDA	J:251621
Cellular Component	GO:0005739	mitochondrion	IDA	J:233904
Cellular Component	GO:0005634	nucleus	TAS	J:203468
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0036047	peptidyl-lysine demalonylation	ISO	J:164563
Biological Process	GO:0036047	peptidyl-lysine demalonylation	IMP	J:180637
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	IMP	J:177830
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	ISO	J:164563
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	IMP	J:180637
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	IBA	J:265628
Biological Process	GO:0036049	peptidyl-lysine desuccinylation	IMP	J:251621
Biological Process	GO:0061698	protein deglutarylation	IDA	J:213152
Biological Process	GO:0061698	protein deglutarylation	ISO	J:164563
Biological Process	GO:0036046	protein demalonylation	IDA	J:213152
Biological Process	GO:0036046	protein demalonylation	ISO	J:164563
Biological Process	GO:0036048	protein desuccinylation	IMP	J:203468
Biological Process	GO:0036048	protein desuccinylation	IDA	J:213152
Biological Process	GO:0036048	protein desuccinylation	ISO	J:164563
Biological Process	GO:0036048	protein desuccinylation	IMP	J:205910
Biological Process	GO:0010566	regulation of ketone biosynthetic process	IMP	J:205910
Biological Process	GO:1904229	regulation of succinate dehydrogenase activity	IMP	J:251621
Biological Process	GO:0002931	response to ischemia	IMP	J:251621