GO Annotations Graph

• Symbol: Mfn1
• Name: mitofusin 1
• ID: MGI:1914664

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005525	GTP binding	IEA	J:72247
Molecular Function	GO:0005525	GTP binding	IEA	J:60000
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:204661
Molecular Function	GO:0005515	protein binding	IPI	J:211366
Molecular Function	GO:0005515	protein binding	IPI	J:186336
Molecular Function	GO:0005515	protein binding	IPI	J:81438
Molecular Function	GO:0005515	protein binding	IPI	J:81438
Molecular Function	GO:0005515	protein binding	IPI	J:186336
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0098799	outer mitochondrial membrane protein complex	ISO	J:164563
Biological Process	GO:0046039	GTP metabolic process	ISO	J:164563
Biological Process	GO:0048312	intracellular distribution of mitochondria	ISO	J:155856
Biological Process	GO:0008053	mitochondrial fusion	IMP	J:211366
Biological Process	GO:0008053	mitochondrial fusion	IGI	J:281198
Biological Process	GO:0008053	mitochondrial fusion	ISO	J:164563
Biological Process	GO:0008053	mitochondrial fusion	IMP	J:281198
Biological Process	GO:0008053	mitochondrial fusion	IBA	J:265628
Biological Process	GO:0008053	mitochondrial fusion	IMP	J:81438
Biological Process	GO:0051646	mitochondrion localization	ISO	J:164563
Biological Process	GO:0051646	mitochondrion localization	IBA	J:265628
Biological Process	GO:0070584	mitochondrion morphogenesis	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0090258	negative regulation of mitochondrial fission	ISO	J:155856
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0010636	positive regulation of mitochondrial fusion	ISO	J:155856
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	IGI	J:281198