GO Annotations Graph

• Symbol: Smurf2
• Name: SMAD specific E3 ubiquitin protein ligase 2
• ID: MGI:1913563

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:148693
Molecular Function	GO:0046332	SMAD binding	ISO	J:155856
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	ISO	J:155856
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TAS	Reactome:R-MMU-5632644
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5632642
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5632644
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0000151	ubiquitin ligase complex	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IBA	J:265628
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:1901165	positive regulation of trophoblast cell migration	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	ISO	J:164563
Biological Process	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	IBA	J:265628