GO Annotations Graph

• Symbol: Sharpin
• Name: SHANK-associated RH domain interacting protein
• ID: MGI:1913331

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:201885
Molecular Function	GO:0005515	protein binding	IPI	J:170809
Molecular Function	GO:0005515	protein binding	IPI	J:187563
Molecular Function	GO:0005515	protein binding	IPI	J:170302
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0043130	ubiquitin binding	IBA	J:265628
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0071797	LUBAC complex	ISO	J:164563
Cellular Component	GO:0071797	LUBAC complex	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0030262	apoptotic nuclear changes	IMP	J:27806
Biological Process	GO:0030262	apoptotic nuclear changes	IMP	J:27806
Biological Process	GO:0030262	apoptotic nuclear changes	IMP	J:27806
Biological Process	GO:0042742	defense response to bacterium	ISO	J:164563
Biological Process	GO:0008544	epidermis development	IMP	J:27806
Biological Process	GO:0031424	keratinization	IMP	J:27806
Biological Process	GO:0007005	mitochondrion organization	IMP	J:27806
Biological Process	GO:0007005	mitochondrion organization	IMP	J:27806
Biological Process	GO:0007005	mitochondrion organization	IMP	J:27806
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:170809
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:170810
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:170809
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:170810
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0097039	protein linear polyubiquitination	ISO	J:164563
Biological Process	GO:0097039	protein linear polyubiquitination	IBA	J:265628
Biological Process	GO:2000348	regulation of CD40 signaling pathway	ISO	J:164563
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:170809
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	IMP	J:170810