GO Annotations Graph

• Symbol: Sh3rf1
• Name: SH3 domain containing ring finger 1
• ID: MGI:1913066

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005078	MAP-kinase scaffold activity	IPI	J:205863
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:143669
Molecular Function	GO:0005515	protein binding	IPI	J:117513
Molecular Function	GO:0005515	protein binding	IPI	J:205863
Molecular Function	GO:0005515	protein binding	IPI	J:261829
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0030027	lamellipodium	IDA	J:261829
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0001764	neuron migration	IMP	J:261829
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:261832
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:205863
Biological Process	GO:0046330	positive regulation of JNK cascade	IBA	J:265628
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	IBA	J:265628
Biological Process	GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	IMP	J:261832
Biological Process	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	IMP	J:205863