GO Annotations Graph

• Symbol: Ripk2
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 2
• ID: MGI:1891456

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0050700	CARD domain binding	ISO	J:73065
Molecular Function	GO:0089720	caspase binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0004706	JUN kinase kinase kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0030274	LIM domain binding	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-741383
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IMP	J:175412
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IMP	J:75401
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IMP	J:75400
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:75401
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:75400
Biological Process	GO:0071223	cellular response to lipoteichoic acid	IMP	J:75400
Biological Process	GO:0071225	cellular response to muramyl dipeptide	ISO	J:164563
Biological Process	GO:0071224	cellular response to peptidoglycan	IMP	J:75400
Biological Process	GO:0032602	chemokine production	IMP	J:75400
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IMP	J:75401
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:75401
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:132126
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:75400
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:75400
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IDA	J:132126
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:175412
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:132126
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:75401
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:75400
Biological Process	GO:0033080	immature T cell proliferation in thymus	IMP	J:75400
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0045087	innate immune response	IMP	J:175412
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0032623	interleukin-2 production	IMP	J:75400
Biological Process	GO:0032635	interleukin-6 production	IMP	J:75400
Biological Process	GO:0032635	interleukin-6 production	IMP	J:132126
Biological Process	GO:0007254	JNK cascade	IMP	J:132126
Biological Process	GO:0007254	JNK cascade	IMP	J:75401
Biological Process	GO:0007254	JNK cascade	IMP	J:75400
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	IMP	J:75400
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:75400
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:132126
Biological Process	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway	IMP	J:75400
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO	J:164563
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP	J:75400
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	IDA	J:88212
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP	J:75401
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP	J:75400
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:75400
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	IMP	J:75401
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:75400
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	J:132126
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:75400
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:73065
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:132126
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:75401
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	IMP	J:75400
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IMP	J:75400
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:205032
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:75400
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:132126
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:132126
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:75401
Biological Process	GO:0046330	positive regulation of JNK cascade	IMP	J:75400
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:132126
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:75400
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:75400
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	IMP	J:75400
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:205032
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:87716
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0032092	positive regulation of protein binding	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	IMP	J:132126
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	IMP	J:75401
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	IMP	J:75400
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	IMP	J:75401
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	IMP	J:75401
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:205032
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:132126
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IMP	J:75400
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:75401
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:75400
Biological Process	GO:1904417	positive regulation of xenophagy	IMP	J:178691
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0042981	regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0043330	response to exogenous dsRNA	IMP	J:75400
Biological Process	GO:0070555	response to interleukin-1	IMP	J:75400
Biological Process	GO:0070671	response to interleukin-12	IMP	J:75401
Biological Process	GO:0070671	response to interleukin-12	IMP	J:75400
Biological Process	GO:0070673	response to interleukin-18	IMP	J:75401
Biological Process	GO:0070673	response to interleukin-18	IMP	J:75400
Biological Process	GO:0051403	stress-activated MAPK cascade	IMP	J:132126
Biological Process	GO:0051403	stress-activated MAPK cascade	IMP	J:75400
Biological Process	GO:0051403	stress-activated MAPK cascade	IMP	J:75401
Biological Process	GO:0042098	T cell proliferation	IMP	J:87716
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:175412
Biological Process	GO:0050852	T cell receptor signaling pathway	IMP	J:75400
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	ISO	J:73065
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	IMP	J:75400
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:132126
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:75400
Biological Process	GO:0032609	type II interferon production	IMP	J:75401
Biological Process	GO:0032609	type II interferon production	IMP	J:75400
Biological Process	GO:0098792	xenophagy	IMP	J:178691