GO Annotations Graph

• Symbol: Txnip
• Name: thioredoxin interacting protein
• ID: MGI:1889549

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004857	enzyme inhibitor activity	IDA	J:62834
Molecular Function	GO:0005515	protein binding	IPI	J:138150
Molecular Function	GO:0005515	protein binding	IPI	J:138150
Molecular Function	GO:0005515	protein binding	IPI	J:62834
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:62834
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1250247
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1250256
Cellular Component	GO:0005758	mitochondrial intermembrane space	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0071228	cellular response to tumor cell	ISO	J:164563
Biological Process	GO:0030216	keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0051782	negative regulation of cell division	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:138150
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:138150
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP	J:117491
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0006606	protein import into nucleus	IMP	J:138150
Biological Process	GO:0015031	protein transport	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	IDA	J:62834