GO Annotations Graph

• Symbol: Asah2
• Name: N-acylsphingosine amidohydrolase 2
• ID: MGI:1859310

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0102121	ceramidase activity	IEA	J:72245
Molecular Function	GO:0071633	dihydroceramidase activity	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	IDA	J:269646
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ISO	J:155856
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	IMP	J:269550
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	ISO	J:164563
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	IBA	J:265628
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity	IDA	J:61655
Molecular Function	GO:0070774	phytoceramidase activity	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:269642
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005901	caveola	IDA	J:269642
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:102906
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:61655
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:269550
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005886	plasma membrane	IDA	J:102906
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:269642
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0046513	ceramide biosynthetic process	IMP	J:269550
Biological Process	GO:0046513	ceramide biosynthetic process	ISO	J:155856
Biological Process	GO:0046514	ceramide catabolic process	IMP	J:110485
Biological Process	GO:0046514	ceramide catabolic process	IDA	J:269646
Biological Process	GO:0046514	ceramide catabolic process	ISO	J:155856
Biological Process	GO:0046514	ceramide catabolic process	IMP	J:102906
Biological Process	GO:0046514	ceramide catabolic process	IBA	J:265628
Biological Process	GO:0044241	lipid digestion	IMP	J:110485
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0042759	long-chain fatty acid biosynthetic process	IBA	J:265628
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0006665	sphingolipid metabolic process	IEA	J:60000
Biological Process	GO:0046512	sphingosine biosynthetic process	IMP	J:110485
Biological Process	GO:0046512	sphingosine biosynthetic process	IMP	J:102906
Biological Process	GO:0046512	sphingosine biosynthetic process	ISO	J:155856
Biological Process	GO:0046512	sphingosine biosynthetic process	IDA	J:269646
Biological Process	GO:0046512	sphingosine biosynthetic process	IBA	J:265628