GO Annotations Graph

• Symbol: Clic4
• Name: chloride intracellular channel 4
• ID: MGI:1352754

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005254	chloride channel activity	ISO	J:155856
Molecular Function	GO:0005254	chloride channel activity	IBA	J:265628
Molecular Function	GO:0005254	chloride channel activity	ISO	J:58963
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005911	cell-cell junction	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0034707	chloride channel complex	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISS	J:58963
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IDA	J:58963
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:146487
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IMP	J:146487
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:164563
Biological Process	GO:1902476	chloride transmembrane transport	ISO	J:58963
Biological Process	GO:0006821	chloride transport	IBA	J:265628
Biological Process	GO:0006821	chloride transport	ISO	J:58963
Biological Process	GO:0001886	endothelial cell morphogenesis	IMP	J:146487
Biological Process	GO:0009566	fertilization	IMP	J:146487
Biological Process	GO:0030216	keratinocyte differentiation	ISO	J:164563
Biological Process	GO:0030216	keratinocyte differentiation	IMP	J:124999
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0035264	multicellular organism growth	IMP	J:146487
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	IMP	J:146487
Biological Process	GO:0007035	vacuolar acidification	IMP	J:146487