GO Annotations Graph

• Symbol: Pla2g10
• Name: phospholipase A2, group X
• ID: MGI:1347522

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	ISO	J:164563
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	IDA	J:80718
Molecular Function	GO:0047498	calcium-dependent phospholipase A2 activity	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004623	phospholipase A2 activity	ISO	J:155856
Molecular Function	GO:0004620	phospholipase activity	IMP	J:174125
Molecular Function	GO:0004620	phospholipase activity	IMP	J:232433
Molecular Function	GO:0005543	phospholipid binding	IBA	J:265628
Cellular Component	GO:0001669	acrosomal vesicle	IDA	J:161461
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Biological Process	GO:0050482	arachidonic acid secretion	IEA	J:72247
Biological Process	GO:0007411	axon guidance	ISO	J:100820
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:174125
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0043249	erythrocyte maturation	IMP	J:232433
Biological Process	GO:0009566	fertilization	IMP	J:232433
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:170945
Biological Process	GO:0036335	intestinal stem cell homeostasis	IMP	J:238240
Biological Process	GO:0016042	lipid catabolic process	IEA	J:72247
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0051977	lysophospholipid transport	ISO	J:100820
Biological Process	GO:0042116	macrophage activation	IDA	J:232433
Biological Process	GO:0090370	negative regulation of cholesterol efflux	IDA	J:174125
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:232433
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:232433
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:232433
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:232433
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	IMP	J:232433
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IMP	J:174125
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IBA	J:265628
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:232433
Biological Process	GO:0046473	phosphatidic acid metabolic process	ISO	J:164563
Biological Process	GO:0046473	phosphatidic acid metabolic process	IDA	J:80718
Biological Process	GO:0034638	phosphatidylcholine catabolic process	ISO	J:164563
Biological Process	GO:0046470	phosphatidylcholine metabolic process	ISO	J:164563
Biological Process	GO:0046470	phosphatidylcholine metabolic process	IDA	J:80718
Biological Process	GO:0046337	phosphatidylethanolamine metabolic process	ISO	J:164563
Biological Process	GO:0046337	phosphatidylethanolamine metabolic process	IDA	J:80718
Biological Process	GO:0046337	phosphatidylethanolamine metabolic process	IMP	J:170945
Biological Process	GO:0046471	phosphatidylglycerol metabolic process	ISO	J:164563
Biological Process	GO:0046471	phosphatidylglycerol metabolic process	IDA	J:80718
Biological Process	GO:0006658	phosphatidylserine metabolic process	ISO	J:164563
Biological Process	GO:0006658	phosphatidylserine metabolic process	IDA	J:80718
Biological Process	GO:0006644	phospholipid metabolic process	IBA	J:265628
Biological Process	GO:0006644	phospholipid metabolic process	IMP	J:232433
Biological Process	GO:0006644	phospholipid metabolic process	IMP	J:232433
Biological Process	GO:0062234	platelet activating factor catabolic process	ISO	J:164563
Biological Process	GO:2000344	positive regulation of acrosome reaction	IMP	J:161461
Biological Process	GO:0090238	positive regulation of arachidonic acid secretion	IDA	J:174125
Biological Process	GO:0010884	positive regulation of lipid storage	ISO	J:164563
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	ISO	J:164563
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:164563
Biological Process	GO:0002532	production of molecular mediator involved in inflammatory response	IDA	J:232433
Biological Process	GO:0002532	production of molecular mediator involved in inflammatory response	IMP	J:232433
Biological Process	GO:0001516	prostaglandin biosynthetic process	IDA	J:238240
Biological Process	GO:0043030	regulation of macrophage activation	ISO	J:164563