GO Annotations Graph

• Symbol: Bace1
• Name: beta-site APP cleaving enzyme 1
• ID: MGI:1346542

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IMP	J:276403
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IDA	J:229208
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:116162
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:91545
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	ISO	J:155856
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:155532
Molecular Function	GO:0005515	protein binding	IPI	J:276403
Molecular Function	GO:0005515	protein binding	IPI	J:95653
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:73257
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:237673
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:73257
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IDA	J:229208
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IDA	J:232987
Cellular Component	GO:0005768	endosome	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:138795
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IMP	J:138795
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:263411
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:263411
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:263411
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:100835
Cellular Component	GO:0005771	multivesicular body	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:276403
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IMP	J:116162
Cellular Component	GO:0098793	presynapse	IDA	J:263411
Cellular Component	GO:0098793	presynapse	IDA	J:263411
Cellular Component	GO:0098793	presynapse	IDA	J:263411
Cellular Component	GO:0055037	recycling endosome	IDA	J:266459
Cellular Component	GO:0055037	recycling endosome	ISO	J:164563
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:164563
Cellular Component	GO:0005802	trans-Golgi network	IDA	J:232987
Cellular Component	GO:0005802	trans-Golgi network	IBA	J:265628
Biological Process	GO:0042987	amyloid precursor protein catabolic process	IGI	J:277904
Biological Process	GO:0034205	amyloid-beta formation	ISO	J:164563
Biological Process	GO:0050435	amyloid-beta metabolic process	ISO	J:155856
Biological Process	GO:0050435	amyloid-beta metabolic process	ISO	J:164563
Biological Process	GO:0050435	amyloid-beta metabolic process	IBA	J:265628
Biological Process	GO:0050435	amyloid-beta metabolic process	IDA	J:229208
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IMP	J:276403
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0006509	membrane protein ectodomain proteolysis	IBA	J:265628
Biological Process	GO:0007613	memory	TAS	J:239203
Biological Process	GO:0050804	modulation of chemical synaptic transmission	TAS	J:238454
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IGI	J:238454
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0060134	prepulse inhibition	ISO	J:155856
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:138795
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:138795
Biological Process	GO:0016485	protein processing	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IDA	J:91545
Biological Process	GO:0048167	regulation of synaptic plasticity	TAS	J:239203
Biological Process	GO:0140448	signaling receptor ligand precursor processing	IMP	J:116162