GO Annotations Graph

• Symbol: Adamts5
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
• ID: MGI:1346321

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004175	endopeptidase activity	IMP	J:302455
Molecular Function	GO:0050840	extracellular matrix binding	IDA	J:207187
Molecular Function	GO:0008201	heparin binding	IDA	J:207187
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	ISO	J:164563
Molecular Function	GO:0004222	metalloendopeptidase activity	TAS	J:225399
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:326911
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:56831
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IEA	J:72247
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IDA	J:207187
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:225399
Biological Process	GO:0042742	defense response to bacterium	IGI	J:203149
Biological Process	GO:0003203	endocardial cushion morphogenesis	IGI	J:225399
Biological Process	GO:0022617	extracellular matrix disassembly	IMP	J:302455
Biological Process	GO:0030198	extracellular matrix organization	TAS	J:225399
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:0007520	myoblast fusion	IMP	J:302455
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:262354
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0003184	pulmonary valve morphogenesis	IMP	J:225399